An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging
Recent studies have demonstrated that the DNA methylome changes with age. This
epigenetic drift may have deep implications for cellular differentiation and disease …
epigenetic drift may have deep implications for cellular differentiation and disease …
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
[HTML][HTML] Genome-wide methylation profiles reveal quantitative views of human aging rates
The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …
many fields, including disease prevention and treatment, forensics, and extension of life …
Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis
S Li, L Christiansen, K Christensen, TA Kruse… - Scientific reports, 2017 - nature.com
Aging is a complex biological process regulated by multiple cellular pathways and
molecular mechanisms including epigenetics. Using genome-wide DNA methylation data …
molecular mechanisms including epigenetics. Using genome-wide DNA methylation data …
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Aging is associated with progressive and site-specific changes in DNA methylation (DNAm).
These global changes are captured by DNAm clocks that accurately predict chronological …
These global changes are captured by DNAm clocks that accurately predict chronological …
[HTML][HTML] Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
Background DNA methylation is an epigenetic mark associated with the repression of gene
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
Age-related variations in the methylome associated with gene expression in human monocytes and T cells
LM Reynolds, JR Taylor, J Ding, K Lohman… - Nature …, 2014 - nature.com
Age-related variations in DNA methylation have been reported; however, the functional
relevance of these differentially methylated sites (age-dMS) are unclear. Here we report …
relevance of these differentially methylated sites (age-dMS) are unclear. Here we report …
Continuous aging of the human DNA methylome throughout the human lifespan
Å Johansson, S Enroth, U Gyllensten - PloS one, 2013 - journals.plos.org
DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …