The past decade has revealed neuroinflammation as an important mechanism of major
depressive disorder (MDD). Nod-like receptors family pyrin domain containing 3 (NLRP3) …

Major depressive disorder (MDD) is associated with repeated exposure to environmental
stress. Autophagy is activated under various stress conditions that are associated with …

Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions
of people worldwide. The alarming estimated rates of prevalence and relapse make it a …

Background Evidence suggests that microglia-mediated processes are implicated in the
pathophysiology of major depressive disorder (MDD). The relationship between these …

Mounting evidence suggests a significant correlation between depressive disorders and
neurodegenerative conditions, encompassing Alzheimer's disease and Parkinson's disease …

Depressive disorders are widely debilitating psychiatric disease. Despite the considerable
progress in the field of depression therapy, extensive research spanning many decades has …

Astrocyte dysfunctions have been consistently observed in patients affected with depression
and other psychiatric illnesses. Although over the years our understanding of these …

Background Major depressive disorder (MDD) is a common but severe psychiatric illness
characterized by depressive mood and diminished interest. Both nucleotide-binding …

Despite intense ongoing research efforts, the etiology of psychiatric disorders remains
incompletely understood. Among biological factors playing a role in Major Depressive …

The neuropathology of psychiatric disorders has long been of interest in psychiatry.
However, only a small number of three-dimensional quantitative studies have been …