Human post-mortem brain studies have revealed reduced density and size of neurons and
glial cells in the dorsolateral prefrontal cortex (dlPFC) in major depressive disorder (MDD) …

Dysfunction of the glial cells, such as astrocytes and microglia, is one of the pathological
features in many psychiatric disorders, including depression, which emphasizes that glial …

Disrupted synaptic plasticity is the hallmark of major depressive disorder (MDD), with
accompanying changes at the molecular and cellular levels. Often, the maladaptive …

Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders
affecting over one-fifth of the population worldwide. Owing to our limited understanding of …

Aims: The SLC6A15 gene has been identified as a novel candidate gene for major
depressive disorder (MDD). However, the mechanism underlying the effects of how the …

Long interspersed nuclear element-1 (LINE-1 or L1) is a type of retrotransposons comprising
17% of the human and mouse genome, and has been found to be associated with several …

Depression is a highly prevalent disorder that poses a significant social burden to society.
Despite continued advances toward the understanding of the pathophysiology of this …

Background Major depressive disorder (MDD) is a prevalent mental health condition with
significant societal impact. Owing to the intricate biological diversity of MDD, treatment …

Background Development of anxiety-and depression-like states under chronic social defeat
stress in mice has been shown by many experimental studies. In this article, the differentially …

Background: Depression is a mental disorder that poses a serious threat to human health.
Adult hippocampal neurogenesis (AHN) is closely associated with the efficacy of …