Major depressive disorder (MDD) is a complex illness that involves the interaction of
different brain systems, pathways, and cell types. Past molecular studies of MDD relied on …

NLRP3 inflammasome pathway-mediated inflammatory response is closely associated with
depression. Increasing attention has been recently paid to the links between autophagy and …

Astrocytes have become promising new agents against major depressive disorders (MDD)
primarily due to the crucial role they play in the pathogenesis of such disorders. However, a …

Inflammation is a prominent hypothesis in the neurobiology of depression. In our
transcriptomic profiling study of microglia in chronic major depressive disorder (MDD), we …

Clinical and preclinical studies suggest that hippocampal astrocyte dysfunction is involved in
the pathophysiology of depression; however, the underlying molecular mechanisms remain …

Autophagy is a process preserving the balance between synthesis, degradation and
recycling of cellular components and is therefore essential for neuronal survival and …

Background An overlap of clinical symptoms between major depressive disorder (MDD) and
social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain …

Major depressive disorder (MDD) is a chronic debilitating illness affecting yearly 300 million
people worldwide. Oligodendrocyte-lineage cells have emerged as important …

Late-life depression (LLD) has a complex and multifactoral etiology. There is growing
interest in elucidating how glia, acting alone or as part of a glial–neuronal network, may …

Objective This study is designed to investigate the gray matter volume (GMV) deficits in
patients with first-episode medication-naïve major depressive disorder (MDD). Methods We …