Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

There have been a large number of reports about glial cell dysfunction being related to
major psychiatric diseases such as schizophrenia (SCZ), bipolar disorder (BD), and major …

The adult brain retains a high repopulation capacity of astrocytes after deletion, and both
mature astrocytes in the neocortex and neural stem cells in neurogenic regions possess the …

Background Abnormalities in functional connectivity (FC) in major depressive disorder
(MDD) have been widely reported. Analysis of the relationship between FC and plasma lipid …

Previous human postmortem studies have shown that expression of glutamate transporters
(SLC1A2 and SLC1A3) and gamma-aminobutyric acid-synthesizing enzyme [glutamic acid …

Recent studies have suggested that mitochondrial dysfunction and dysregulated
neuroinflammatory pathways are involved in the pathophysiology of major depressive …

Autism spectrum disorders (ASDs) are neurodevelopmental disorders caused by various
genetic and environmental factors that result in synaptic abnormalities. ASD development is …

Several structural and cellular changes, including marked glial anomalies, have been
observed in association with major depressive disorder. Here we review these cellular …

Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …

Emerging evidence has documented the abnormalities of primary brain functions in major
depressive disorder (MDD). The brainstem has shown to play an important role in regulating …