The etiopathogenesis of late-onset Alzheimer's disease (AD) is increasingly recognized as
the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and …

Background To establish whether major depressive disorder (MDD), suicidal behaviors and
psychotic features contribute to glial alterations in the human prefrontal cortex. Materials and …

Abstract Major Depressive Disorder (MDD) is a commonly observed psychiatric disorder that
affects more than 2% of the world population with a rising trend. However, disease …

Cognitive impairment is highly prevalent among individuals with late-life depression (LLD)
and tends to persist even after successful treatment. The biological mechanisms underlying …

Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …

Background Major depressive disorder (MDD) is a common mental illness that affects
millions of people worldwide and imposes a heavy burden on individuals, families and …

Deficits in astrocyte function contribute to major depressive disorder (MDD) and suicide, but
the therapeutic effect of directly reactivating astrocytes for depression remains unclear. Here …

The first demonstrations that the levels of inflammatory cytokines are elevated in patients
with depression (1) and that exposure to an inflammatory challenge produces a …

Depression is a common disease that affects physical and mental health and imposes a
considerable burden on afflicted individuals and their families worldwide. Depression is …

Background: Norepinephrine and glutamate are among several neurotransmitters
implicated in the neuropathology of major depressive disorder (MDD). Glia deficits have also …