Integrative omics analysis identifies differential biological pathways that are associated with regional grey matter volume changes in major depressive disorder
Z Sha, L Banihashemi - Psychological Medicine, 2022 - cambridge.org
BackgroundMajor depressive disorder (MDD) is accompanied by alterations in grey matter
volume. However, the biological processes associated with regional structural perturbations …
volume. However, the biological processes associated with regional structural perturbations …
Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder
Background The SLC6A15 gene has been identified as a novel candidate gene for major
depressive disorder (MDD). It is presumed to be involved in the pathophysiology of MDD …
depressive disorder (MDD). It is presumed to be involved in the pathophysiology of MDD …
Integrated analysis of transcriptional changes in major depressive disorder: Insights from blood and anterior cingulate cortex
X Zhong, X Chen, Y Liu, S Gui, J Pu, D Wang, W Tao… - Heliyon, 2024 - cell.com
Background Major depressive disorder (MDD) was involved in widely transcriptional
changes in central and peripheral tissues. While, previous studies focused on single tissues …
changes in central and peripheral tissues. While, previous studies focused on single tissues …
[HTML][HTML] In vitro methods in autophagy research: Applications in neurodegenerative diseases and mood disorders
DI Sánchez-Vidaña, J Li, S Abokyi… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Autophagy is a conserved physiological intracellular mechanism responsible
for the degradation and recycling of cytoplasmic constituents (eg, damaged organelles, and …
for the degradation and recycling of cytoplasmic constituents (eg, damaged organelles, and …
[HTML][HTML] Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depression
CR Plaska, A Heslegrave, D Bruno… - Brain, Behavior, and …, 2024 - Elsevier
Major depressive disorder (MDD) is associated with Alzheimer's disease (AD) but the
precise mechanisms underlying this relationship are not understood. While it is well …
precise mechanisms underlying this relationship are not understood. While it is well …
Evidence for Reduced Anti-Inflammatory Microglial Phagocytic Response in Late-Life Major Depression
C Reichert Plaska, A Heslegrave… - Brain, Behavior, and … - researchonline.ljmu.ac.uk
Major depressive disorder (MDD) is associated with Alzheimer's disease (AD) but the
precise mechanisms underlying this relationship are not understood. While it is well …
precise mechanisms underlying this relationship are not understood. While it is well …
Downregulation of adhesion molecule CHL1 in B cells but not T cells of patients with major depression and in the brain of mice with chronic stress
CR Yang, L Ning, FH Zhou, Q Sun, HP Meng… - Neurotoxicity …, 2020 - Springer
Depression is a common serious mental disorder with unclear pathogenesis. Currently,
specific diagnostic biomarkers are yet to be characterized. The close homolog of L1 (CHL1) …
specific diagnostic biomarkers are yet to be characterized. The close homolog of L1 (CHL1) …
Transcriptional substrates of brain structural and functional impairments in drug-naive first-episode patients with major depressive disorder
Q Fang, H Cai, P Jiang, H Zhao, Y Song, W Zhao… - Journal of Affective …, 2023 - Elsevier
Background Despite remarkable success in identifying genetic risk factors for depression,
there are still open questions about the exact genetic mechanisms underlying certain …
there are still open questions about the exact genetic mechanisms underlying certain …
Signatures of 4 autophagy-related genes as diagnostic markers of MDD and their correlation with immune infiltration
S He, Z Deng, Z Li, W Gao, D Zeng, Y Shi… - Journal of affective …, 2021 - Elsevier
Background Major depressive disorder (MDD) is a debilitating mental illness and one of the
primary causes of suicide. This study attempted to develop and validate a multigene joint …
primary causes of suicide. This study attempted to develop and validate a multigene joint …
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder
Abstract Major Depressive Disorder (MDD) is a common psychiatric disorder for which
available medications are often not effective. The high prevalence of MDD and modest …
available medications are often not effective. The high prevalence of MDD and modest …