Major depressive disorder (MDD) has an enormous impact on global disease burden,
affecting millions of people worldwide and ranking as a leading cause of disability for almost …

Major depressive disorder is a severe and the most prevalent form of neuropsychiatric
disorder that affects millions of individuals worldwide. The current treatment focuses on brain …

Glucocorticoids are released from the adrenal cortex and are important for regulating
various physiological functions. However, a persistent increase in glucocorticoids due to …

Although multiple hypotheses had been proposed to clarify the causes of depression, the
accurate pathogenesis and effective treatment of depression still need to be solved …

Emerging evidence suggests that astrocyte loss is one of the most important pathological
features in the hippocampus of patients with major depressive disorder (MDD) and …

Significant stress exposure and psychiatric depression are associated with morphological,
biochemical, and physiological disturbances of astrocytes in specific brain regions relevant …

Glutamatergic mechanisms and resting-state functional connectivity alterations have been
recently described as factors contributing to major depressive disorder (MDD). Furthermore …

Autophagy is a process of degradation and recycling of cytoplasmatic components by the
lysosomes. In the central nervous system (CNS), autophagy is involved in cell surveillance …

Major depressive disorder (MDD) is a debilitating neuropsychiatric illness affecting over
20% of the population worldwide. Despite its prevalence, our understanding of its …

Microglial activation-induced neuroinflammation is closely associated with the development
of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological …