[HTML][HTML] Oligodendrocyte lineage cells and depression
B Zhou, Z Zhu, BR Ransom, X Tong - Molecular psychiatry, 2021 - nature.com
Depression is a common mental illness, affecting more than 300 million people worldwide.
Decades of investigation have yielded symptomatic therapies for this disabling condition but …
Decades of investigation have yielded symptomatic therapies for this disabling condition but …
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression
Several studies have proposed that brain glutamate signaling abnormalities and glial
pathology have a role in the etiology of major depressive disorder (MDD). These …
pathology have a role in the etiology of major depressive disorder (MDD). These …
[HTML][HTML] Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway
Y Fang, X Ding, Y Zhang, L Cai, Y Ge, K Ma… - Journal of …, 2022 - Springer
Background Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to
directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby …
directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby …
[HTML][HTML] ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex
Hyperexcitability in the orbitofrontal cortex (OFC) is a key clinical feature of anhedonic
domains of Major Depressive Disorder (MDD). However, the cellular and molecular …
domains of Major Depressive Disorder (MDD). However, the cellular and molecular …
Transcriptome alterations in prefrontal pyramidal cells distinguish schizophrenia from bipolar and major depressive disorders
Background Impairments in certain cognitive processes (eg, working memory) are typically
most pronounced in schizophrenia (SZ), intermediate in bipolar disorder, and least in major …
most pronounced in schizophrenia (SZ), intermediate in bipolar disorder, and least in major …
Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity
SP Pantazatos, YY Huang, GB Rosoklija… - Molecular …, 2017 - nature.com
Brain gene expression profiling studies of suicide and depression using oligonucleotide
microarrays have often failed to distinguish these two phenotypes. Moreover, next …
microarrays have often failed to distinguish these two phenotypes. Moreover, next …
Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder
C Aston, L Jiang, BP Sokolov - Molecular psychiatry, 2005 - nature.com
Major depressive disorder is one of the most common and devastating psychiatric disorders.
To identify candidate mechanisms for major depressive disorder, we compared gene …
To identify candidate mechanisms for major depressive disorder, we compared gene …
[HTML][HTML] Evidence for structural and functional alterations of frontal-executive and corticolimbic circuits in late-life depression and relationship to mild cognitive …
N Rashidi-Ranjbar, D Miranda, MA Butters… - Frontiers in …, 2020 - frontiersin.org
Depression is a risk factor for developing Alzheimer's disease and Related Dementia
(ADRD). We conducted a systematic review between 2008 and October 2018, to evaluate …
(ADRD). We conducted a systematic review between 2008 and October 2018, to evaluate …
White matter abnormalities in major depression: evidence from post-mortem, neuroimaging and genetic studies
BACKGROUND: Until more recently, most studies have examined the changes in brain gray
matter in major depressive disorder (MDD) with less studies focusing on understanding …
matter in major depressive disorder (MDD) with less studies focusing on understanding …
The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder–Fine‐Grained Meta‐Analyses
Background. While the brain correlates of major depressive disorder (MDD) have been
extensively studied, there is no consensus conclusion so far. Various meta‐analyses tried to …
extensively studied, there is no consensus conclusion so far. Various meta‐analyses tried to …