Environmental risks of chemicals are still often assessed substance-by-substance,
neglecting mixture effects. This may result in risk underestimations, as the typical exposure …

Regulatory limit values are generally set for single compounds. However, humans are
exposed both simultaneously and sequentially to a wide variety of compounds. Some …

The risk assessment process must encompass all available toxicological data and scientific
evidence on the plausible toxicities of a chemical or chemical mixture. As an extension to the …

This Guidance document describes harmonised risk assessment methodologies for
combined exposure to multiple chemicals for all relevant areas within EFSA's remit, ie …

A literature review covering the last 14 yr has been performed in the field of combination
toxicology and human risk assessment from exposure to chemical mixtures, with special …

Unintentional chemical mixtures that are present in the environment are of societal concern
as the (environmental) chemicals contained therein, either singly or in combination, may …

The article focuses on the quantitative prediction and assessment of chemical mixture
toxicity. It provides an overview of a series of studies designed to test multi-component …

With the goal of assessing the environmental risk of pharmaceuticals, we have previously
observed that a mixture of 13 different drugs at environmentally relevant concentrations had …

Objectives In this commentary we analyze how much data will in fact be generated within
REACH. Conclusions We conclude that the data requirements for many end points still have …

Chemicals are used to make virtually every man-made regard to their production,
formulation, use and disposal. product and play an important role in the everyday life It will …