[HTML][HTML] Post-traumatic osteoarthritis: a review of pathogenic mechanisms and novel targets for mitigation

JE Dilley, MA Bello, N Roman, T McKinley, U Sankar - Bone Reports, 2023 - Elsevier
Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …

[HTML][HTML] Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention

WC Kramer, KJ Hendricks, J Wang - International journal of clinical …, 2011 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is characterized by joint pain and stiffness with radiographic evidence of
joint space narrowing, osteophytes, and subchondral bone sclerosis. Posttraumatic OA …

Post-traumatic arthritis: definitions and burden of disease

JA Buckwalter, DT Felson - Post-traumatic arthritis: pathogenesis …, 2015 - Springer
Osteoarthritis, as distinguished from arthritis secondary to inflammatory or neurologic
disorders, is the most common form of joint disease and is one of the leading causes of …

[HTML][HTML] Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment

J Riegger, RE Brenner - International journal of molecular sciences, 2020 - mdpi.com
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …

Pathogenesis and prevention of posttraumatic osteoarthritis after intra-articular fracture

ML Schenker, RL Mauck, J Ahn… - JAAOS-Journal of the …, 2014 - journals.lww.com
Posttraumatic osteoarthritis (PTOA) occurs after traumatic injury to the joint. It is most
common following injuries that disrupt the articular surface or lead to joint instability. The …

Pathogenesis of post-traumatic OA with a view to intervention

EA Riordan, C Little, D Hunter - Best Practice & Research Clinical …, 2014 - Elsevier
Post-traumatic osteoarthritis (PTOA) subsequent to joint injury accounts for over 12% of the
overall disease burden of OA, and higher in the most at-risk ankle and knee joints. Evidence …

Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis

JA Buckwalter, TD Brown - Clinical Orthopaedics and Related …, 2004 - journals.lww.com
Joint injuries, especially intraarticular fractures, frequently lead to progressive joint
degeneration that causes the clinical syndrome of posttraumatic osteoarthritis. Orthopaedists …

Key pathways to prevent posttraumatic arthritis for future molecule-based therapy

S Chubinskaya, MA Wimmer - Cartilage, 2013 - journals.sagepub.com
Joint injuries are common, especially among young adults aged 18 to 44 years. They are
accompanied by a cascade of events that increase the risk of posttraumatic osteoarthritis …

The role of subchondral bone damage in post‐traumatic osteoarthritis

TR Coughlin, OD Kennedy - Annals of the New York Academy …, 2016 - Wiley Online Library
Osteoarthritis (OA), the most common musculoskeletal disease in the United States, is
characterized by cartilage breakdown, pain, and restricted movement. Post‐traumatic OA …

Post‐traumatic osteoarthritis: improved understanding and opportunities for early intervention

DD Anderson, S Chubinskaya, F Guilak… - Journal of …, 2011 - Wiley Online Library
Even with current treatments of acute joint injuries, more than 40% of people who suffer
significant ligament or meniscus tears, or articular surface injuries, will develop osteoarthritis …