Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a bridging
role in innate immunity and adaptive immunity. The activated TLRs not only induce …

Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells
and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in …

ABSTRACT Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses
exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in …

Abstract Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly
located intracellularly in immune cells, including dendritic cells, macrophages, natural killer …

Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important
group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded …

Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition molecules. Since
the discovery of the Toll pathway cascade (1, 2), our knowledge about the structure, function …

From the numerous Toll-like receptor agonists, only TLR7 agonists have been approved for
cancer treatment, although they are current restricted to topical application. The main target …

Since first being described in the fruit fly Drosophila melanogaster, Toll-like receptors (TLRs)
have proven to be of great interest to immunologists and investigators interested in the …

The discovery of the TLRs family and more precisely its functions opened a variety of gates
to modulate immunological host responses. TLRs 7/8 are located in the endosomal …

Purpose: The immunomodulatory properties of Toll-like receptors (TLR) agonists have
inspired their use as experimental adjuvants for vaccination of cancer patients. However, it is …