Pre‐synaptic dopamine D3 receptor mediates cocaine‐induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways
G Collo, F Bono, L Cavalleri, L Plebani… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 765–778. Abstract Exposure to psychostimulants results in
neuroadaptive changes of the mesencephalic dopaminergic system including …
neuroadaptive changes of the mesencephalic dopaminergic system including …
Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling
L Cavalleri, E Merlo Pich, MJ Millan, C Chiamulera… - Molecular …, 2018 - nature.com
Among neurobiological mechanisms underlying antidepressant properties of ketamine,
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …
Enhanced peripheral levels of BDNF and proBDNF: elucidating neurotrophin dynamics in cocaine use disorder
M Pettorruso, A Miuli, K Clemente, G Mancusi… - Molecular …, 2024 - nature.com
Brain-derived neurotrophic factor (BDNF) and its precursor, proBDNF, are known to
significantly contribute to brain homeostasis, neuroplasticity, and neuronal remodeling …
significantly contribute to brain homeostasis, neuroplasticity, and neuronal remodeling …
Dopamine D1 and N-methyl-D-aspartate receptors and extracellular signal-regulated kinase mediate neuronal morphological changes induced by repeated cocaine …
Z Ren, WL Sun, H Jiao, D Zhang, H Kong, X Wang… - Neuroscience, 2010 - Elsevier
The development of drug addiction involves persistent cellular and molecular changes in the
CNS. The brain dopamine and glutamate systems play key roles in mediating drug-induced …
CNS. The brain dopamine and glutamate systems play key roles in mediating drug-induced …
Structural plasticity associated with exposure to drugs of abuse
TE Robinson, B Kolb - Neuropharmacology, 2004 - Elsevier
Persistent changes in behavior and psychological function that occur as a function of
experience, such those associated with learning and memory, are thought to be due to the …
experience, such those associated with learning and memory, are thought to be due to the …
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic
regions of brain thought to be responsible for long-term behavioral plasticity driving …
regions of brain thought to be responsible for long-term behavioral plasticity driving …
Increased central brain-derived neurotrophic factor activity could be a risk factor for substance abuse: Implications for treatment
SJ Tsai - Medical hypotheses, 2007 - Elsevier
Drug addiction is a common psychiatric disorder with complex genetic, psychological and
social contributing factors. While the midbrain dopaminergic system is crucial for acute …
social contributing factors. While the midbrain dopaminergic system is crucial for acute …
Update of neurotrophic factors in neurobiology of addiction and future directions
Drug addiction is a chronic brain disease and drugs of abuse cause long lasting
neuroadaptations. Addiction is characterized by the loss of control over drug use despite …
neuroadaptations. Addiction is characterized by the loss of control over drug use despite …
Opiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons
MS Mazei-Robison, EJ Nestler - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
The study of neuronal adaptations induced by opiate drugs is particularly relevant today
given their widespread prescription and nonprescription use. Although much is known about …
given their widespread prescription and nonprescription use. Although much is known about …
Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond
The neuroadaptation theory of addiction suggests that, similar to the development of most
memories, exposure to drugs of abuse induces adaptive molecular and cellular changes in …
memories, exposure to drugs of abuse induces adaptive molecular and cellular changes in …