J. Neurochem.(2012) 120, 765–778. Abstract Exposure to psychostimulants results in
neuroadaptive changes of the mesencephalic dopaminergic system including …

Among neurobiological mechanisms underlying antidepressant properties of ketamine,
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …

Brain-derived neurotrophic factor (BDNF) and its precursor, proBDNF, are known to
significantly contribute to brain homeostasis, neuroplasticity, and neuronal remodeling …

The development of drug addiction involves persistent cellular and molecular changes in the
CNS. The brain dopamine and glutamate systems play key roles in mediating drug-induced …

Persistent changes in behavior and psychological function that occur as a function of
experience, such those associated with learning and memory, are thought to be due to the …

Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic
regions of brain thought to be responsible for long-term behavioral plasticity driving …

Drug addiction is a common psychiatric disorder with complex genetic, psychological and
social contributing factors. While the midbrain dopaminergic system is crucial for acute …

Drug addiction is a chronic brain disease and drugs of abuse cause long lasting
neuroadaptations. Addiction is characterized by the loss of control over drug use despite …

The study of neuronal adaptations induced by opiate drugs is particularly relevant today
given their widespread prescription and nonprescription use. Although much is known about …

The neuroadaptation theory of addiction suggests that, similar to the development of most
memories, exposure to drugs of abuse induces adaptive molecular and cellular changes in …