Toll-like receptors involved in the response to microbial pathogens: development of agonists for toll-like receptor 9.
C Schetter, J Vollmer - Current Opinion in Drug Discovery & …, 2004 - europepmc.org
Upon microbial infection, a host has to mount a multiplicity of immune responses that target
the invading pathogen. This is achieved in part by the use of particular receptors expressed …
the invading pathogen. This is achieved in part by the use of particular receptors expressed …
Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of Toll-like receptor 9
J Kindrachuk, JE Potter, R Brownlie, AD Ficzycz… - Journal of Biological …, 2007 - ASBMB
Toll-like receptor 9 (TLR9) activates the innate immune system in response to microbial DNA
or mimicking oligodeoxynucleotides. Although cell stimulation experiments demonstrate the …
or mimicking oligodeoxynucleotides. Although cell stimulation experiments demonstrate the …
Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation
M Jurk, J Vollmer - BioDrugs, 2007 - Springer
Vertebrate toll-like receptors (TLRs) sense invading pathogens by recognizing bacterial and
viral structures and, as a result, activate innate and adaptive immune responses. Ten human …
viral structures and, as a result, activate innate and adaptive immune responses. Ten human …
Agonists of Toll-like receptor 9: modulation of host immune responses with synthetic oligodeoxynucleotides
T Rich, ER Kandimalla, S Agrawal - Toll and Toll-Like Receptors: An …, 2005 - Springer
Innate immunity is the body's first line of defense against invading microbes. This component
of our immune system relies on highly conserved pattern-recognition receptors (PRRs) to …
of our immune system relies on highly conserved pattern-recognition receptors (PRRs) to …
Toll-like receptors: emerging targets of immunomodulation
VFJ Quesniaux, B Ryffel - Expert Opinion on Therapeutic Patents, 2004 - Taylor & Francis
Toll-like receptors (TLRs) were shown to play a critical role in the recognition and activation
of pathogens by the innate immune system. Pathogen engagement of the TLR–myeloid …
of pathogens by the innate immune system. Pathogen engagement of the TLR–myeloid …
Necessity of oligonucleotide aggregation for toll-like receptor 9 activation
CCN Wu, J Lee, E Raz, M Corr, DA Carson - Journal of Biological …, 2004 - ASBMB
Toll-like receptor 9 (TLR9), a member of the interleukin-1 (IL-1) family of pathogen-
associated molecular pattern receptors, is activated by unmethylated CpG-containing …
associated molecular pattern receptors, is activated by unmethylated CpG-containing …
Targeting of Toll-like receptors: a decade of progress in combating infectious diseases
Toll-like receptors (TLRs) recognise highly conserved molecular structures, collectively
known as pathogen-associated molecular patterns. In the past two decades, development …
known as pathogen-associated molecular patterns. In the past two decades, development …
Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
TLR3 agonists as immunotherapeutic agents
CF Nicodemus, JS Berek - Immunotherapy, 2010 - Taylor & Francis
The interaction of innate and adaptive immune responses is extremely complex and just
beginning to be understood in detail. The tendency for biomedical research to establish …
beginning to be understood in detail. The tendency for biomedical research to establish …
Toll like receptor-potential drug targets in infectious disease
F Erard, B Ryffel - … Drug Targets (Formerly Current Drug Targets …, 2008 - ingentaconnect.com
Toll like receptors (TLR) play a critical role in the recognition and response of pathogens by
the innate immune system. Pathogen engagement of the TLR-MyD88 pathway favours the …
the innate immune system. Pathogen engagement of the TLR-MyD88 pathway favours the …