Despite recent improvements in the diagnosis and treatment of cryptococcosis, cryptococcal
meningitis is responsible for> 600,000 deaths/year worldwide. The aim of this work is to …

The significance of cryptococcal infection as a cause of human disease has dramatically
evolved in recent years. The objective of this study was to outline the worldwide significance …

Key Points Cryptococcal Disease in Diverse Hosts Worldwide, cryptococcal meningitis kills
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …

Background Combination antifungal therapy (amphotericin B deoxycholate and flucytosine)
is the recommended treatment for cryptococcal meningitis but has not been shown to reduce …

Cryptococcosis is a global invasive mycosis associated with significant morbidity and
mortality. These guidelines for its management have been built on the previous Infectious …

Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Cryptococcal meningitis causes morbidity and mortality worldwide. The burden of disease is
greatest in middle-and low-income countries with a high incidence of human …

Cryptococcus neoformans is the most common cause of fungal meningitis in HIV and non-
HIV-infected patients. The organism has a worldwide distribution, with cases typically …

Cryptococcal meningitis persists as a significant source of morbidity and mortality in persons
with HIV/AIDS, particularly in sub-Saharan Africa. Despite increasing access to …

Background Cryptococcal meningitis accounts for more than 100,000 human
immunodeficiency virus (HIV)–related deaths per year. We tested two treatment strategies …