The dose dependence of the hepatopromoting effects of phenobarbital (PB) was
investigated in a rat liver medium-term bioassay (Ito test) to elucidate a practical threshold …

The dose—response of phenobarbitat (PB) promotion of hepatocarcinogenesis in rats was
investigated. Male F344 rats were given 1, 4, 16, 75, 300 or 1200 ppm PB solutions given ad …

Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine;
subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg …

Sequential feeding of various dose levels of phenobarbital (PB) after diethylnitrosamine
(DENA) administration revealed that the enhancing effect of PB on hepatocarcinogenesis …

The dose dependence of the promoting effects of the α-isomer of benzene hexachloride (α-
BHC) on hepatocarcinogenesis was investigated in a medium-term rat liver bioassay (Ito …

The potential hepatocarcinogenicity of seven pesticides was examined using a rapid
bioassay based on the induction of glutathione S-transferase placental form positive foci in …

Subchronic toxicity and long-term tumor-promoting effects of phenobarbital (PB) were
investigated in male Syrian golden hamsters. In subchronic studies, PB was administered in …

The promotion potential of phenobarbital (PB) and 3′-methyl-4-dimethylaminoazobenzene
(3′-Me-DAB) on liver carcinogenesis after initiation with various doses of …

An initiation/promotion bioassay for chemical carcinogens and tumor promoters has been
developed in rat liver using presumed preneoplastic lesions, foci of gamma …

A single dose of 15 mg/kg dimethylnitrosamine is an initiator of hepatic tumour formation in
rats but does not produce tumours without further treatment. Subsequent promotion by Na …