We examined the effect of chronic human renin infusion and human renin inhibition on
blood pressure in a unique transgenic rat model. We infused incremental doses of human …

We studied the effects of extremely low-dose human renin inhibition (aliskiren) with low
angiotensin II receptor blockade (losartan) in a novel double-transgenic rat model …

Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the
pathophysiological progression of heart failure. Species differences in the amino acid …

Renin is predominantly expressed in juxtaglomerular cells in the kidney and regulates blood
pressure homeostasis. To examine possible in vivo functions of a mouse distal enhancer …

The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and
developmental regulation, is present in both the circulation and in many individual tissues …

Since the first description of renin, angiotensinogen and angiotensin as well as converting
enzyme and angiotensin receptors in the brain exactly 30 years ago, 1–5 there was a …

We reported previously that targeted expression of rat prorenin to the liver under the control
of the human α1-antitrypsin promoter increased plasma prorenin levels by several-hundred …

Hypertension is a polygenic and multi‐factorial disorder that is extremely prevalent in
western societies, and thus has received a great deal of attention by the research …

Thirteen years ago, Véniant et al1 made the intriguing observation that targeted expression
of rat prorenin to the liver under the control of the human α1-antitrypsin promoter increased …

Objective To characterize the effect of β-adrenergic activation on renal production of renin in
the intact organism. Design and Methods Renal expression of renin [renin messenger RNA …