In the heart, secretory renin promotes hypertrophy, apoptosis, necrosis, fibrosis, and cardiac
failure through angiotensin generation from angiotensinogen. Thus, inhibitors of the renin …

6. Lutterotti N von, Catanzaro DF, Sealey JE, Laragh JH (1994) Renin is not synthesized by
cardiac and extrarenal vascular tissues. A review of experimental evidence. Circulation 89 …

The renin-angiotensin system plays a major role in the regulation of blood pressure and
electrolyte homeostasis in mammals. In this study, we subjected transgenic mice containing …

The blood pressure–independent effects of angiotensin II (Ang II) were examined in double
transgenic rats (dTGR) harboring human renin and human angiotensinogen genes, in which …

Essential hypertension is an insidious disease in which the afflicted person risks disability
and death from myocardial infarction and stroke. Many factors contribute to the development …

Introduction Controlling hypertension by angiotensin converting enzyme inhibitors (ACEI) or
angiotensin receptor blockers (ARB), mechanisms that inhibit later pathway steps in the …

Inhibition of the renin angiotensin system has beneficial effects in cardiovascular prevention
and treatment. The advent of orally active direct renin inhibitors adds a novel approach to …

The renin-angiotensin system is normally subject to servo control mechanisms that suppress
plasma renin levels in response to increased blood pressure and increase plasma renin …

Hypertension is one of the most important risk factors and a leading cause of death from
cardiovascular and cerebrovascular diseases. Based on numerous previous studies …

The classical secretory renin-a is known to be involved in angiotensin generation, thereby
regulating not only blood pressure, but also promoting oxidative stress as well as apoptotic …