Metabolic syndrome (MetS) is a cluster of factors that increase the risk of developing
diabetes, stroke, and heart failure. The pathophysiology of injury by ischemia/reperfusion …

Background—Peroxisome proliferator–activated receptor-α (PPAR-α) is expressed in the
heart and regulates genes involved in myocardial fatty acid oxidation (FAO). The role of …

Heart failure still remains one of the leading causes of morbidity and mortality worldwide. A
major contributing factor is reactive oxygen/nitrogen species (RONS) overproduction which …

Owing to its high fat content, the classical Western diet has a range of adverse effects on the
heart, including enhanced inflammation, hypertrophy, and contractile dysfunction …

Background/Aims: Cardiac remodeling is a common pathophysiological change along with
chronic hypertension and myocardial infarction. Recent evidence indicated that cardiac …

Activation of peroxisome proliferator-activated receptor (PPAR)-γ, a nuclear transcription
factor, has been shown to inhibit the production of proinflammatory cytokines and, in …

Aims Peroxisome proliferator-activated receptor (PPAR)-α is downregulated in ischemic
myocardium resulting in substrate switch from fatty acid oxidation to glucose utilization …

The cytoskeleton serves an important role in maintaining cellular morphology and function,
and it is a substrate of calpain during myocardial ischemia/reperfusion (I/R) injury (MIRI) …

Myocardial ischemia initiates a chain of pathological conditions leading to cardiomyocyte
death. Therefore, pharmacological treatment to stop ischemia-induced damage is …

Peroxisome proliferator-activated receptor (PPAR)-δ is a transcription factor that belongs to
the PPAR family. PPAR-δ is abundantly expressed in the heart, and its role in the heart is …