The V‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently
dysregulated in colorectal cancer (CRC). It is involved in the modulation of several …

Colorectal cancer (CRC) is a heterogeneous disease with a myriad of alterations at the
cellular and molecular levels. Kristen rat sarcoma (KRAS) mutations occur in up to 40% of …

KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …

Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels.
Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in …

Kirsten rat sarcoma virus oncogene homolog (KRAS) is the most frequently mutated
oncogene in human cancer. In colorectal cancer (CRC), KRAS mutations are present in …

Abstract Purpose of Review Mutations in kirsten rat sarcoma viral oncogene homolog
(KRAS) are the most frequently observed genomic alterations in human cancers. No KRAS …

The prognosis of metastatic colorectal cancer (mCRC) remains poor regardless of the
advances obtained in recent years with new therapeutic agents, surgical procedures, and …

Abstract Kirsten Rat Sarcoma (KRAS) gene somatic point mutations is one of the most
prominently mutated proto-oncogenes known to date, and accounts for approximately 60 …

Objective: Mutant KRAS, the principal isoform of RAS, plays a pivotal role in the
oncogenesis of colorectal cancer by constitutively activating the RAF/MEK/ERK and …

Developing drugs that target KRAS, the most frequently mutated oncogene in cancer, has
not been successful despite much concerted efforts dedicated towards it in the last thirty …