Revisiting epithelial‐mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness

TT Liao, MH Yang - Molecular oncology, 2017 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is an important process in embryonic
development, fibrosis, and cancer metastasis. During cancer progression, the activation of …

Epithelial–mesenchymal transition in tumor metastasis

KT Yeung, J Yang - Molecular oncology, 2017 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) is a developmental program that enables
stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells …

Epithelial–mesenchymal plasticity in carcinoma metastasis

JH Tsai, J Yang - Genes & development, 2013 - genesdev.cshlp.org
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. Metastasis occurs through a series of steps …

Epithelial–mesenchymal transition in cancer development and its clinical significance

M Iwatsuki, K Mimori, T Yokobori, H Ishi… - Cancer …, 2010 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) plays a critical role in embryonic development.
EMT is also involved in cancer progression and metastasis and it is probable that a common …

Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

M Diepenbruck, G Christofori - Current opinion in cell biology, 2016 - Elsevier
An epithelial to mesenchymal transition (EMT) is a process of cell remodeling critical during
embryonic development and organogenesis. During an EMT, epithelial cells lose their …

Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis

JJ Christiansen, AK Rajasekaran - Cancer research, 2006 - AACR
For most carcinomas, progression toward malignancy is accompanied by loss of epithelial
differentiation and a shift towards a mesenchymal phenotype. This process, referred to as …

Epithelial mesenchymal transition in tumor metastasis

V Mittal - Annual Review of Pathology: Mechanisms of Disease, 2018 - annualreviews.org
Metastasis is the major cause of cancer-related deaths; therefore, the prevention and
treatment of metastasis are fundamental to improving clinical outcomes. Epithelial …

EMT and MET: necessary or permissive for metastasis?

MK Jolly, KE Ware, S Gilja, JA Somarelli… - Molecular …, 2017 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …

Insights into cancer metastasis from a clinicopathologic perspective: Epithelial‐Mesenchymal Transition is not a necessary step

MH Chui - International journal of cancer, 2013 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) has been implicated as the critical event initiating
cancer invasion and metastasis. After disseminating through the circulation, the malignant …