Neuroinflammation is a proinflammatory cytokine-mediated process that can be provoked by
systemic tissue injury but it is most often associated with direct injury to the nervous system …

Cytokine activation or dysregulation is implied in a variety of painful disease states.
Numerous experimental studies provide evidence that proinflammatory cytokines induce or …

Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known
roles have extended from within the immune system to include a neuro-inflammatory domain …

Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …

Background Neuropathic pain is a challenging condition often refractory to existing
therapies. An increasing number of studies have indicated that the immune system plays a …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Neuropathic pain originates from a damage or disease affecting the somatosensory system.
Its treatment is unsatisfactory as it appears refractory to most analgesics. Animal models of …

Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion
or disease of the somatosensory nervous system. Albeit the elucidation of numerous …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …