[HTML][HTML] Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia
D Verlekar, SJ Wei, H Cho, S Yang, MH Kang - Cell death & disease, 2018 - nature.com
Ceramide synthases (CERS) produce ceramides which are key intermediators in the
biosynthesis of complex sphingolipids and play an important role in cell proliferation …
biosynthesis of complex sphingolipids and play an important role in cell proliferation …
N-(4-hydroxyphenyl) retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes
PH O'Donnell, WX Guo, CP Reynolds, BJ Maurer - Leukemia, 2002 - nature.com
Abstract The retinoid, N-(4-hydroxyphenyl) retinamide (4-HPR), mediates p53-independent
cytotoxicity and can increase reactive oxygen species and ceramide in solid tumor cell lines …
cytotoxicity and can increase reactive oxygen species and ceramide in solid tumor cell lines …
Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 …
G Kong, D Wang, H Wang, J Wu, J Bielawski… - Leukemia, 2008 - nature.com
2-Cyano-3, 12-dioxooleana-1, 9-diene-28-oic acid (CDDO) and its derivatives, methyl-2-
cyano-3, 12-dioxooleana-1, 9-diene-28-oate (CDDO-Me) and 2-cyano-3, 12-dioxooleana-1 …
cyano-3, 12-dioxooleana-1, 9-diene-28-oate (CDDO-Me) and 2-cyano-3, 12-dioxooleana-1 …
Ceramide regulates cellular homeostasis via diverse stress signaling pathways
PP Ruvolo - Leukemia, 2001 - nature.com
The sphingolipid ceramide is an important second signal molecule that regulates diverse
signaling pathways involving apoptosis, cell senescence, the cell cycle, and differentiation …
signaling pathways involving apoptosis, cell senescence, the cell cycle, and differentiation …
Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells
L Jiang, X Pan, Y Chen, K Wang, Y Du… - … and biophysical research …, 2011 - Elsevier
Leukemic cells responding to apoptosis-inducing drugs can be varied in terms of the
mechanisms of action. Fenretinide, a synthetic retinoid, is worth of study as a promising …
mechanisms of action. Fenretinide, a synthetic retinoid, is worth of study as a promising …
[HTML][HTML] Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide
D Myrick, D Blackinton, J Klostergaard, N Kouttab… - Leukemia research, 1999 - Elsevier
We hypothesized that the lipid second messenger, ceramide, and microtubule-directed
chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our …
chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our …
Reactive oxygen species mediate N-(4-hydroxyphenyl) retinamide-induced cell death in malignant T cells and are inhibited by the HTLV-I oncoprotein Tax
N Darwiche, G Abou-Lteif, A Bazarbachi - Leukemia, 2007 - nature.com
Abstract N-(4-hydroxyphenyl) retinamide (HPR) is a synthetic retinoid that inhibits growth of
many human tumor cells, including those resistant to natural retinoids. HPR is an effective …
many human tumor cells, including those resistant to natural retinoids. HPR is an effective …
[HTML][HTML] Ceramide synthase 6 is a novel target of methotrexate mediating its antiproliferative effect in a p53-dependent manner
B Fekry, A Esmaeilniakooshkghazi, SA Krupenko… - PLoS …, 2016 - journals.plos.org
We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate
stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis …
stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis …
[HTML][HTML] Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de …
Abstract Background and Objectives Arsenic trioxide (ATO) is an effective treatment for acute
promyelocytic leukemia (APL) and potentially for human T-cell leukemia virus type I (HTLV-I) …
promyelocytic leukemia (APL) and potentially for human T-cell leukemia virus type I (HTLV-I) …
Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells
Resveratrol, an important phytoalexin in many plants, has been reported to have cytotoxic
effects on various types of cancer. Ceramide is a bioactive sphingolipid that regulates many …
effects on various types of cancer. Ceramide is a bioactive sphingolipid that regulates many …