The tyrosine kinase inhibitor, imatinib, is the first line of treatment for chronic myeloid
leukemia (CML) patients. Unfortunately, patients develop resistance and relapse due to bcr …

Abstract N-(4-hydroxyphenyl) retinamide (HPR) is a synthetic retinoid that inhibits growth
and induces apoptosis in many human cell lines. We explored the effects of HPR on human …

Ceramide is the key intermediate in the pathway of sphingolipid (SL) 2 biosynthesis (1) and
an important intracellular signaling molecule (2, 3). Ceramide consists of a sphingoid long …

Sphingolipid-mediated regulation in cancer development and treatment is largely ceramide-
centered with the complex sphingolipid metabolic pathways unfolding as attractive targets …

The cytotoxic effects of several chemotherapeutic drugs have been linked to elevated de
novo ceramide biosynthesis. However, the relationship between the intracellular site (s) of …

Treatment of A549 cells with C 6-ceramide resulted in a significant increase in the
endogenous long chain ceramide levels, which was inhibited by fumonisin B1 (FB1), and …

The objective of our study was to determine the mechanism of action of the short-chain
ceramide analog, C6-ceramide, and the breast cancer drug, tamoxifen, which we show …

The sphingolipids are a diverse family of lipids with important roles in membrane
compartmentalization, intracellular signaling, and cell-cell recognition. The central …

The role of ceramide neo-genesis in cellular stress response signaling is gaining increasing
attention with recent progress in elucidating the novel roles and biochemical properties of …

We examined the effects of a cell-permeable ceramide analog, C2-ceramide, on the growth
of TNF-alpha-resistant B lymphoma Raji cells lacking TNF-alpha-receptors (TNF-R). C2 …