The anticancer properties of ceramide, a sphingolipid with potent tumor-suppressor
properties, can be dampened via glycosylation, notably in multidrug resistance wherein …

Purpose: Taxol has emerged as a valuable antimitotic chemotherapeutic agent, particularly
in advanced breast and ovarian cancers. Although much is known about cytotoxic …

Stichoposide D (STD) is a marine triterpene glycoside isolated from sea cucumbers. We
examined the molecular mechanisms underlying the antitumor activity of STD in human …

Multidrug-resistance is a major cause of cancer chemotherapy failure in clinical treatment.
Evidence shows that multidrug-resistant cancer cells are as sensitive as corresponding …

Recent evidence suggests a role for aberrant ceramide levels in the pathogenesis of cancer
and chemoresistance and indicates that manipulation of tumor ceramide levels may be a …

In lymphocytes, Fas activation leads to both apoptosis and necrosis, whereby the latter form
of cell death is linked to delayed production of endogenous ceramide and is mimicked by …

Sphingolipids, which include ceramides and sphingosine, are essential structural
components of cell membranes that also have messenger functions that regulate the …

Abstract The synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic
acid (CD437), which was originally developed as an retinoic acid receptor (RAR)-γ agonist …

Retinoids such as all‐trans retinoic acid (ATRA) influence cell growth, differentiation and
apoptosis and may play decisive roles in tumor development and progression. An essential …

Abstract Acute Myeloid Leukemia (AML) is a highly heterogeneous and poor prognosis
disease with few available therapeutic options. Novel advances are urgently needed …