Structural study on ligand specificity of human vitamin B12 transporters
Studies comparing the binding of genuine cobalamin (vitamin B12) to that of its natural or
synthetic analogues have long established increasing ligand specificity in the order …
synthetic analogues have long established increasing ligand specificity in the order …
Structural basis for mammalian vitamin B12 transport by transcobalamin
Cobalamin (Cbl, vitamin B12) serves for two essential cofactors in mammals. The pathway
for its intestinal absorption, plasma transport, and cellular uptake uses cell surface receptors …
for its intestinal absorption, plasma transport, and cellular uptake uses cell surface receptors …
Vitamin B12 Transport Proteins: Crystallographic Analysis of β‐axial Ligand Substitutions in Cobalamin Bound to Transcobalamin
Abstract Cobalamin (Cbl, vitamin B12) is an essential micronutrient that is synthesized only
by bacteria. Mammals have developed a complex system for internalization of this vitamin …
by bacteria. Mammals have developed a complex system for internalization of this vitamin …
[HTML][HTML] Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin
E Furger, DC Frei, R Schibli, E Fischer… - Journal of Biological …, 2013 - ASBMB
Cobalamin (Cbl; vitamin B 12) is an essential micronutrient synthesized only by bacteria.
Mammals have developed a sophisticated uptake system to capture the vitamin from the …
Mammals have developed a sophisticated uptake system to capture the vitamin from the …
Mechanisms of Discrimination between Cobalamins and Their Natural Analogues during Their Binding to the Specific B12-Transporting Proteins
SN Fedosov, NU Fedosova, B Kräutler, E Nexø… - Biochemistry, 2007 - ACS Publications
Three proteins, intrinsic factor (IF), transcobalamin (TC), and haptocorrin (HC), all have an
extremely high affinity for the cobalamins (Cbls, K d≈ 5 fM) but discriminate these …
extremely high affinity for the cobalamins (Cbls, K d≈ 5 fM) but discriminate these …
In meso structure of the cobalamin transporter, BtuB, at 1.95 Å resolution
Crystals of the apo form of the vitamin B12 and colicin receptor, BtuB, that diffract to 1.95 Å
have been grown by the membrane-based in meso technique. The structure of the protein …
have been grown by the membrane-based in meso technique. The structure of the protein …
[PDF][PDF] Absorption and Transport of Cobalamin(Vitamin B 12)
B Seetharam, DH Alpers - Annual review of nutrition, 1982 - researchgate.net
344 SEETHARAM & ALPERS tions leading to cobalamin deficiency present especially to the
first two of these specialties. Many recent advances involve biochemical definition of the …
first two of these specialties. Many recent advances involve biochemical definition of the …
Absorption and Transport of Vitamin B12
R Gräsbeck - British Journal of Haematology, 1975 - Wiley Online Library
A review of recent advances is presented, mostly dealing with physiological mechanisms
and the chemical and functional properties of the transport proteins. A new nomenclature is …
and the chemical and functional properties of the transport proteins. A new nomenclature is …
The binding properties of the human receptor for the cellular uptake of vitamin B12
EV Quadros, Y Nakayama, JM Sequeira - Biochemical and biophysical …, 2005 - Elsevier
Cellular uptake of vitamin B12 (cobalamin, Cbl) is mediated by a receptor expressed on the
plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the …
plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the …
Cobalamin binding proteins
E Nexo - Vitamin B, 1998 - books.google.com
Intrinsic factor, transcobalamin and haptocorrin are the three cobalamin binding proteins
involved in the uptake and transport of cobalamins in mammals. Intrinsic factor transports …
involved in the uptake and transport of cobalamins in mammals. Intrinsic factor transports …