Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–
cell interactions in processes as diverse as tissue development, immune cell trafficking and …

Multicellular systems, from bacterial biofilms to human organs, form interfaces (or
boundaries) between different cell collectives to spatially organize versatile functions,. The …

Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity
and wound healing,. Focal adhesions are multifunctional organelles that mediate cell–ECM …

The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

A common theme in the self-organization of multicellular tissues is the use of cell-cell
signaling networks to induce morphological changes. We used the modular synNotch …

Cells can sense the density and distribution of extracellular matrix (ECM) molecules by
means of individual integrin proteins and larger, integrin-containing adhesion complexes …

Membrane-bound receptors often form large assemblies resulting from binding to soluble
ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example …

Multicellularity in animals requires dynamic maintenance of cell–cell contacts. Intercellularly
ligated cadherins recruit numerous proteins to form supramolecular complexes that connect …

To the editor: Adhesion complexes in cells growing on planar substrates have been studied
for over three decades. From these studies, several classes of adhesions have been …

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