Programming multicellular assembly with synthetic cell adhesion molecules
Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–
cell interactions in processes as diverse as tissue development, immune cell trafficking and …
cell interactions in processes as diverse as tissue development, immune cell trafficking and …
4-bit adhesion logic enables universal multicellular interface patterning
H Kim, DJ Skinner, DS Glass, AE Hamby, BAR Stuart… - Nature, 2022 - nature.com
Multicellular systems, from bacterial biofilms to human organs, form interfaces (or
boundaries) between different cell collectives to spatially organize versatile functions,. The …
boundaries) between different cell collectives to spatially organize versatile functions,. The …
Nanoscale architecture of integrin-based cell adhesions
Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity
and wound healing,. Focal adhesions are multifunctional organelles that mediate cell–ECM …
and wound healing,. Focal adhesions are multifunctional organelles that mediate cell–ECM …
Adhesion protein structure, molecular affinities, and principles of cell-cell recognition
The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …
they" recognize" one another with high specificity. We discuss recent progress in …
Programming self-organizing multicellular structures with synthetic cell-cell signaling
A common theme in the self-organization of multicellular tissues is the use of cell-cell
signaling networks to induce morphological changes. We used the modular synNotch …
signaling networks to induce morphological changes. We used the modular synNotch …
Force loading explains spatial sensing of ligands by cells
Cells can sense the density and distribution of extracellular matrix (ECM) molecules by
means of individual integrin proteins and larger, integrin-containing adhesion complexes …
means of individual integrin proteins and larger, integrin-containing adhesion complexes …
Transforming binding affinities from three dimensions to two with application to cadherin clustering
Membrane-bound receptors often form large assemblies resulting from binding to soluble
ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example …
ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example …
Nanoscale architecture of cadherin-based cell adhesions
Multicellularity in animals requires dynamic maintenance of cell–cell contacts. Intercellularly
ligated cadherins recruit numerous proteins to form supramolecular complexes that connect …
ligated cadherins recruit numerous proteins to form supramolecular complexes that connect …
Reducing background fluorescence reveals adhesions in 3D matrices
KE Kubow, AR Horwitz - Nature cell biology, 2011 - nature.com
To the editor: Adhesion complexes in cells growing on planar substrates have been studied
for over three decades. From these studies, several classes of adhesions have been …
for over three decades. From these studies, several classes of adhesions have been …
Interactome under construction
L Bonetta - Nature, 2010 - nature.com
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