Background Substantial efforts have been made to identify clinically meaningful non-
abstinence cocaine use outcomes by establishing associations between targeted drug use …

Background Establishing a non-abstinence cocaine use outcome as clinically meaningful
has been elusive, in part due to the lack of association between cocaine use outcomes and …

Background Assessment instruments commonly used in clinical trials to measure functional
outcomes in substance users may lack sensitivity to detect change during treatment …

Background Cocaine use disorder (CUD) is characterized by the continued use of cocaine
despite serious impacts on life. This study focused on understanding the perspective of …

Background Little in known about the extent to which outcome measures used in studies of
the treatment of cocaine dependence are associated with longer-term use and with broader …

Objective: Abstinence outcomes are typically prioritized in the treatment of cocaine use
disorder while ignoring patterns of low-frequency cocaine use. This study examined patterns …

Background Cocaine use contines to be a significant public health problem world‐wide.
However, despite substantial research efforts, no pharmacotherapies are approved for the …

Background Psychosocial approaches are the first-line treatments for cocaine dependence,
although they still present high dropout and relapse rates. Thus, there is a pressing need to …

Cocaine use disorder (CUD) is a devastating disorder, impacting both individuals and
society. Individuals with CUD face many barriers in accessing treatment for CUD, and most …

Background Despite calls for non-abstinence endpoints in randomized clinical trials (RCTs)
for cocaine use disorder, there is a lack of data validating non-abstinence endpoints. We …