Cellular aging towards osteoarthritis

YS Li, W Xiao, W Luo - Mechanisms of ageing and development, 2017 - Elsevier
Osteoarthritis (OA) is a common form of degenerative joint disease. Aging process is
supposed to be a leading predictor for developing OA. In this review, we have discussed the …

Osteoarthritis: aging of matrix and cells-going for a remedy

T Aigner, J Haag, J Martin, J Buckwalter - Current Drug Targets, 2007 - ingentaconnect.com
It has been known for a very long time that aging is the most prominent risk factor for the
initiation and progression of osteoarthritis. This might be related to continuous mechanical …

[HTML][HTML] Aging, cell senescence, the pathogenesis and targeted therapies of osteoarthritis

XX Zhang, SH He, X Liang, W Li, TF Li… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by progressive
destruction of articular cartilage. For a long time, OA has been considered as a degenerative …

Aging and osteoarthritis: an inevitable encounter?

T Hügle, J Geurts, C Nüesch… - Journal of aging …, 2012 - Wiley Online Library
Osteoarthritis (OA) is a major health burden of our time. Age is the most prominent risk factor
for the development and progression of OA. The mechanistic influence of aging on OA has …

[HTML][HTML] How are aging and osteoarthritis related?

S Wakale, X Wu, Y Sonar, A Sun, X Fan… - Aging and …, 2023 - ncbi.nlm.nih.gov
Osteoarthritis is the most prevalent degenerative joint disease and one of the leading
causes of physical impairment in the world's aging population. The human lifespan has …

[HTML][HTML] The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression

YA Rim, Y Nam, JH Ju - International journal of molecular sciences, 2020 - mdpi.com
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the
adult population. OA is primarily caused by trauma induced by an external force or by age …

Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes

G Musumeci, MA Szychlinska, A Mobasheri - 2015 - digitum.um.es
Aging is a natural process by which every single living organism approaches its twilight of
existence in a natural way. However, aging is also linked to the pathogenesis of a number of …

Aging bone and cartilage: cross-cutting issues

JL Carrington - Biochemical and biophysical research communications, 2005 - Elsevier
Aging is a major risk factor for osteoarthritis and osteoporosis. Yet, these are not necessary
outcomes of aging, and the relationship between age-related changes in bone and cartilage …

Ageing and the pathogenesis of osteoarthritis

RF Loeser, JA Collins, BO Diekman - Nature Reviews Rheumatology, 2016 - nature.com
Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …

Events in articular chondrocytes with aging

DJ Leong, HB Sun - Current Osteoporosis Reports, 2011 - Springer
It is well accepted that aging is one of the most prominent risk factors for the initiation and
progression of osteoarthritis. One of the most pronounced age-related changes in …