N-Methyllaurotetanine (1) has been reported to display good affinity for the 5-HT1A receptor,
but no structure–affinity studies have been performed to date. The commercially available …

Phenylalkylamines such as 1-(4-bromo-2, 5-dimethoxyphenyl)-2-aminopropane (DOB; 1a)
and its corresponding iodo derivative DOI (2) are commonly used 5-HT2 serotonin agonists …

Parthenolide displaces [3H] ketanserin from 5HT2A receptors from rat and rabbit brain and
cloned 5HT2A receptors. K i's are in the 100− 250 μM range. These results suggest that …

−(±)-5-Me-8-OH-DPAT 4 was synthesized by a new synthetic pathway recently described by
us. The (+)-and (−)-enantiomers 4 were prepared from the primary amine 8 by crystallisation …

C1 and flexible analogs of (±)-nantenine were synthesized and evaluated for antagonist
activity at human 5-HT2A receptors in a calcium mobilization assay. This work has resulted …

The enantiomers of cis-andfrarcs-l, 2, 3, 4, 4a, 5, 10, 10a-octahydro-9-hydroxy-l-propylbenzo
[g] quinolines (10 and 11, respectively) and the enantiomers of trans-l, 2, 3, 4, 4a, 5, 6, 10b …

WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl) piperazinyl) ethyl))-N-(2-pyridinyl)
cyclohexanecarboxamide] 1 and its O-desmethyl derivative DWAY 2 are well-known high …

A 5‐HT3 receptor agonist based on a benzamide scaffold was identified in a screening of a
small commercial compound library, and an elaborate SAR study originating from this hit …

A series of new 1-[4-(indol-3-yl) butyl]-4-arylpiperazines was prepared to identify highly
selective and potent 5-HT1A agonists as potential pharmacological tools in studies of mood …

A library consisting of 60 arylpiperazines modified with N-acylated amino acids was
prepared on BAL linker SynPhase™ Lanterns and evaluated in vitro for 5-HT1A receptor …