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This report describes the effect of replacing the central basic amine present in many known
5-HT2A ligands with an aromatic residue. We targeted the isomeric phenethylpyridines 2 …

Janssen's Ketanserin (1), the classical 5-HT2A-receptor (5HT2AR) antagonist [1], was
chosen as the starting point for a search for potent and stereoselective 5HT2AR antagonists …

Arylsulfonyl analogs of aminopyrimidines (eg Ro 04-6790; 2), aminopyridines (eg Ro 63-
0563; 3), 1-phenylpiperazines (eg SB-271046; 4), and tryptamines (eg MS-245; 5) were …

Publisher Summary For 5-HT 2 receptors, many potent ligands belonging to different
chemical classes such as phenylalkylamines, indoles, ergots, 4-aryl (alkyl) piperidines, 4 …

The synthesis and SAR of tolylamines with 5-HT6 receptor antagonist activity is presented.
The amine, core aromatic, peripheral aromatic, and ether linker moieties of HTS hit 1 were …

New substituted benzamides as SHT, receptor antagonists Page 1 Eur J Med Chem (1995)
30,65 l-654 0 Elsevier, Paris 651 Short communication New substituted benzamides as SHT …

Abstract A series of (enantiopure) 8-triflate-substituted 2-(n-propylamino) tetralins has been
synthesized and evaluated for in vitro binding to 5-HT1A, 5-HT1Dα and 5-HT1Dβ receptors …

In this study, the (S)-enantiomers of the aporphine alkaloids, nuciferine and roemerine, were
prepared via a synthetic route involving catalytic asymmetric hydrogenation and both …

The synthesis and 5-HT2A receptor affinities of ring altered derivatives of spiro [9, 10-
dihydroanthracene]-9, 3′-pyrrolidine (4), a structurally unique tetracyclic 5-HT2A receptor …