Autism spectrum disorder (ASD) describes a complex and heterogenous group of
neurodevelopmental disorders. Whole genome sequencing continues to shed light on the …

Aberrant gene expression underlies many human diseases. RNA polymerase II (Pol II)
pausing is a key regulatory step in transcription. Here, we mapped the locations of RNA Pol …

Background Neural tube defects (NTDs) are debilitating birth defects involving the central
nervous system (CNS). Despite recent advances, NTDs represent the second most common …

R-loops are three-stranded nucleic acid structures that accumulate on chromatin in
neurological diseases and cancers and contribute to genome instability. Using a proximity …

Neural tube defects (NTDs) are common birth defects of complex etiology. Though family-
and population-based studies have confirmed a genetic component, the responsible genes …

Intellectual disability (ID) is a highly prevalent disorder that affects 1–3% of the population.
The Aristaless-related homeobox gene (ARX) is a frequently mutated X-linked ID gene and …

In vitro studies indicate the neurodevelopmental disorder gene myelin transcription factor 1-
like (MYT1L) suppresses non-neuronal lineage genes during fibroblast-to-neuron direct …

Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth
defects whose complex multigenic causation has hampered efforts to delineate their …

Abstract In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs
and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan …

Abstract RNA polymerase III (Pol III) includes two alternate isoforms, defined by mutually
exclusive incorporation of subunit POLR3G (RPC7α) or POLR3GL (RPC7β), in mammals …