Comprehensive annotations of the mutational spectra of SARS‐CoV‐2 spike protein: a fast and accurate pipeline

MS Rahman, MR Islam, MN Hoque… - Transboundary and …, 2021 - Wiley Online Library
Infecting millions of people, the SARS‐CoV‐2 is evolving at an unprecedented rate,
demanding advanced and specified analytic pipeline to capture the mutational spectra. In …

Regional and temporal coordinated mutation patterns in SARS-CoV-2 spike protein revealed by a clustering and network analysis

SS Negi, CH Schein, W Braun - Scientific reports, 2022 - nature.com
SARS-CoV-2 has steadily mutated during its spread to> 300 million people throughout the
world. The WHO has designated strains with certain mutations,“variants of concern”(VOC) …

Understanding mutations in human SARS-CoV-2 spike glycoprotein: a systematic review & meta-analysis

R Kumar, Y Srivastava, P Muthuramalingam, SK Singh… - Viruses, 2023 - mdpi.com
Genetic variant (s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to
mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses …

Development of an efficient Sanger sequencing-based assay for detecting SARS-CoV-2 spike mutations

HJ Lim, MY Park, HS Jung, Y Kwon, I Kim, DK Kim… - PLoS …, 2021 - journals.plos.org
Novel strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harboring
nucleotide changes (mutations) in the spike gene have emerged and are spreading rapidly …

SARS-CoV-2 variants and their relevant mutational profiles: update summer 2021

M Alkhatib, V Svicher, R Salpini… - Microbiology …, 2021 - Am Soc Microbiol
Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic caused by it,
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been undergoing a …

High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein

R Suratekar, P Ghosh, MJM Niesen… - Molecular systems …, 2022 - embopress.org
The highly contagious Delta variant of SARS‐CoV‐2 has become a prevalent strain globally
and poses a public health challenge around the world. While there has been extensive …

[HTML][HTML] Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677

EB Hodcroft, DB Domman, DJ Snyder, KY Oguntuyo… - MedRxiv, 2021 - ncbi.nlm.nih.gov
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) plays
critical roles in host cell entry. Non-synonymous substitutions affecting S are not uncommon …

[HTML][HTML] Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

B Korber, WM Fischer, S Gnanakaran, H Yoon… - BioRxiv, 2020 - biorxiv.org
We have developed an analysis pipeline to facilitate real-time mutation tracking in SARS-
CoV-2, focusing initially on the Spike (S) protein because it mediates infection of human …

Local emergence and decline of a SARS-CoV-2 variant with mutations L452R and N501Y in the spike protein

JP Mallm, C Bundschuh, H Kim, N Weidner, S Steiger… - Medrxiv, 2021 - medrxiv.org
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are replacing
the initial wild-type strain, jeopardizing current efforts to contain the pandemic. Amino acid …

[HTML][HTML] A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features

S Fatihi, S Rathore, AK Pathak, D Gahlot… - Current Research in …, 2021 - Elsevier
The recent release of SARS-CoV-2 genomic data from several countries has provided clues
into the potential antigenic drift of the coronavirus population. In particular, the genomic …