In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our
understanding of the neuropeptide calcitonin gene‐related peptide (CGRP) in the …

BACKGROUND AND PURPOSE Calcitonin gene‐related peptide (CGRP) is widely
distributed in the trigeminovascular system and released from sensory fibres of the cranial …

Background To investigate specific brain regions and neural circuits that are responsible for
migraine chronification. Methods We established a mouse model of chronic migraine with …

Calcitonin gene-related peptide (CGRP) is a vasodilator neuropeptide that is expressed in a
subgroup of small neurons in the dorsal root ganglion (DRG), trigeminal, and vagal ganglia …

Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated anti-
migraine efficacy. One remaining question is where do these blockers act? We hypothesized …

Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-
modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest …

Migraine is a highly prevalent neurovascular disorder afflicting more than 15% of the global
population. Nearly three times more females are afflicted by migraine in the 18–50 years …

CGRP is an extensively studied neuropeptide that has been implicated in the
pathophysiology of migraine. While a number of small molecule antagonists against the …

Background Although the involvement of calcitonin gene-related peptide (CGRP) in
migraines is well-established, its specific role in investigating the aura phase, which often …

The benefit reported in a variety of clinical trials by a series of small molecule antagonists for
the calcitonin gene-related peptide (CGRP) receptor, or four monoclonal antibodies against …