The susceptibility of lysosomal membranes in tumor cells to cationic amphiphilic drugs
(CADs) enables CADs to induce lysosomal membrane permeabilization (LMP) and trigger …

Small molecules which activate distinct cell death pathways have promising high potential
for anticancer drug research. Especially, regulated necrosis draws attention as an …

Downregulation of apoptotic signal pathway and activation of protective autophagy mainly
contribute to the chemoresistance of tumor cells. Therefore, exploring efficient …

The autophagy-mediated lysosomal pathway plays an important role in conferring stress
tolerance to tumor cells during cellular stress such as increased metabolic demands. Thus …

A major confounding issue in the successful treatment of cancer is the existence of tumor
cell populations that resist therapeutic agents and regimens. While tremendous effort has …

Drug markets revisits herbal medicines, as historical usages address their therapeutic
efficacies with less adverse effects. Moreover, herbal medicines save both cost and time in …

It is widely accepted that lysosomes are essential for cell homeostasis, and autophagy plays
an important role in tumor development. Here, we found FV-429, a synthetic flavonoid …

(-)-Oleocanthal (OC), a phenolic compound present in extra-virgin olive oil (EVOO), has
been implicated in the health benefits associated with diets rich in EVOO. We investigated …

Resistance of cancer cells to chemotherapy remains a significant problem in oncology.
Mechanisms regulating programmed cell death, including apoptosis, autophagy or necrosis …

The integrity of lysosomes is of vital importance to survival of tumor cells. We demonstrated
that LW-218, a synthetic flavonoid, induced rapid lysosomal enlargement accompanied with …