Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology

T Efferth, F Oesch - Seminars in Cancer Biology, 2021 - Elsevier
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new
treatment indications. Phytochemicals isolated from medicinal plants have been largely …

Alkaloids for cancer prevention and therapy: Current progress and future perspectives

A Mondal, A Gandhi, C Fimognari, AG Atanasov… - European journal of …, 2019 - Elsevier
Alkaloids are important chemical compounds that serve as a rich source for drug discovery.
Numerous alkaloids screened from medicinal plants and herbs showed antiproliferative and …

Update and new insights on future cancer drug candidates from plant-based alkaloids

M Tilaoui, H Ait Mouse, A Zyad - Frontiers in Pharmacology, 2021 - frontiersin.org
Cancer is a complex multifactorial disease that results from alterations in many physiological
and biochemical functions. Over the last few decades, it has become clear that cancer cells …

Therapeutic role of alkaloids and alkaloid derivatives in cancer management

K Olofinsan, H Abrahamse, BP George - Molecules, 2023 - mdpi.com
Cancer is a neoplastic disease that remains a global challenge with a reported prevalence
that is increasing annually. Though existing drugs can be applied as single or combined …

[HTML][HTML] Anticancer alkaloids from trees: Development into drugs

T Isah - Pharmacognosy reviews, 2016 - ncbi.nlm.nih.gov
Trees have made an enormous phytochemical contribution in anticancer drugs'
development more than any other life form. The contributions include alkaloids that are …

Emerging cytotoxic alkaloids in the battle against cancer: Overview of molecular mechanisms

Z Habli, G Toumieh, M Fatfat, ON Rahal… - Molecules, 2017 - mdpi.com
Considered as the second deadliest disease globally, cancer has captured the attention of
researchers who have been trying with perseverance to decode its hidden aspects, to find …

Drug repurposing in cancer

L Sleire, HE Førde, IA Netland, L Leiss, BS Skeie… - Pharmacological …, 2017 - Elsevier
Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

Alkaloids isolated from natural herbs as the anticancer agents

JJ Lu, JL Bao, XP Chen, M Huang… - Evidence‐Based …, 2012 - Wiley Online Library
Alkaloids are important chemical compounds that serve as a rich reservoir for drug
discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and …

Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics

A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Old wine in new bottles: Drug repurposing in oncology

M Antoszczak, A Markowska, J Markowska… - European Journal of …, 2020 - Elsevier
Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …