Understanding the effects of mesenchymal stromal cell therapy for treating osteoarthritis using an in vitro co-culture model

V Shang, J Li, CB Little, JJ Li - bioRxiv, 2022 - biorxiv.org
Osteoarthritis (OA) is a leading cause of chronic pain and disability, for which there is no
cure. Mesenchymal stromal cells (MSCs) have been used in clinical trials for treating OA due …

[HTML][HTML] Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

G Copp, KP Robb, S Viswanathan - Cellular & Molecular Immunology, 2023 - nature.com
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …

Review of patents and commercial opportunities involving Mesenchymal Stromal Cells (MSCs) therapies in osteoarthritis

S Viswanathan… - Recent Patents on …, 2014 - ingentaconnect.com
Osteoarthritis (OA) is a degenerative joint disease that affects cartilage, subchondral bone,
the synovium and synovial fluid and has limited treatment options. With an ageing …

Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial …

J Chahal, A Gómez-Aristizábal… - Stem cells …, 2019 - academic.oup.com
Patients with late-stage Kellgren-Lawrence knee osteoarthritis received a single intra-
articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM-MSCs) …

A bioengineered in vitro osteoarthritis model with tunable inflammatory environments indicates context-dependent therapeutic potential of human mesenchymal stem …

P Diaz-Rodriguez, J Erndt-Marino, H Chen… - Regenerative …, 2019 - Springer
Recently, intra-articular injections of mesenchymal stem cells (MSCs) have been used as a
treatment for early osteoarthritis (OA) due to the known immunomodulatory effects of these …

Recent advances in mesenchymal stem/stromal cells (MSCs)‐based approaches for osteoarthritis (OA) therapy

A Hassanzadeh, N Vousooghi… - Cell Biology …, 2023 - Wiley Online Library
Recently, mesenchymal stem/stromal cells (MSCs) transplantation has been introduced as a
promising option to support cartilage structure and improve its function in preclinical models …

[HTML][HTML] Mesenchymal stromal cells for the treatment of osteoarthritis of knee joint: context and perspective

PK Gupta, C Thej - Annals of Translational Medicine, 2019 - ncbi.nlm.nih.gov
Evidence from completed preclinical and clinical studies conducted worldwide suggests that
mesenchymal stromal cells (MSCs) are a novel and promising option for the treatment of …

[HTML][HTML] Progress in the use of mesenchymal stromal cells for osteoarthritis treatment

X Zhang, J He, W Wang - Cytotherapy, 2021 - Elsevier
Literature review of MSCs in the treatment of osteoarthritis in the past five years
Osteoarthritis (OA) is one of the most common chronic joint diseases, with prominent …

The role of inflammation in mesenchymal stromal cell therapy in osteoarthritis, perspectives for post-traumatic osteoarthritis: a review

WF Theeuwes, MHJ van den Bosch… - …, 2021 - academic.oup.com
OA is a complex and highly prevalent degenerative disease affecting the whole joint, in
which factors like genetic predisposition, gender, age, obesity and traumas contribute to joint …

Mesenchymal stem cell therapy for osteoarthritis: practice and possible promises

N Nasiri, R Nateghi, F Zarei, S Hosseini… - Cell biology and …, 2022 - Springer
Osteoarthritis (OA) is a common progressively degenerative joint disease that affects more
than 300 million people worldwide. OA is manifested by articular cartilage degradation …