Neutrophil-derived cytokines: potential therapeutic targets in inflammation

T Kasama, Y Miwa, T Isozaki, T Odai… - Current Drug Targets …, 2005 - ingentaconnect.com
Polymorphonuclear neutrophils (PMNs) are usually thought of as the leukocyte population
involved in acute inflammatory responses, acting as a first line of defense against invading …

[HTML][HTML] Neutrophil-derived cytokines: facts beyond expression

C Tecchio, A Micheletti, MA Cassatella - Frontiers in immunology, 2014 - frontiersin.org
Polymorphonuclear neutrophils, besides their involvement in primary defense against
infections–mainly through phagocytosis, generation of toxic molecules, release of enzymes …

[PDF][PDF] The neutrophil as a cellular source of chemokines

S Gasperini, F Calzetti, F Bazzoni… - Immunological …, 2000 - academia.edu
Neutrophils are known to play an important role in inflammatory responses by virtue of their
ability to perform a series of effector functions that collectively represent a major mechanism …

Neutrophil-derived proteins: selling cytokines by the pound

MA Cassatella - Advances in immunology, 1999 - Elsevier
Publisher Summary This chapter summarizes the recent knowledge on the production of
cytokines by neutrophils in vitro and in vivo—particularly molecular regulation and other …

The role of neutrophils and monocytes in innate immunity

C Kantari, M Pederzoli-Ribeil… - Trends in Innate Immunity, 2008 - karger.com
Polymorphonuclear neutrophils (PMNs) and monocyte/macrophages (MMs) are
professional phagocytic cells that are able to phagocytose and destroy infectious agents …

Polymorphonuclear leucocytes selectively produce anti‐inflammatory interleukin‐1 receptor antagonist and chemokines, but fail to produce pro‐inflammatory …

AK Schröder, M Von Der Ohe, U Kolling… - …, 2006 - Wiley Online Library
The role of neutrophils in the immune response has long been regarded as mainly
phagocytic, but recent publications have indicated the production of several cytokines by …

Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses

S Yamashiro, H Kamohara, JM Wang… - Journal of leukocyte …, 2001 - academic.oup.com
Polymorphonuclear leukocytes (PMN) are the most abundant leukocytes, comprising about
two-thirds of peripheral blood leukocytes, and play major roles in innate immunity. In …

Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response

AR Lloyd, JJ Oppenheim - Immunology today, 1992 - cell.com
The polymorphonuclear leucocyte (PMN) has traditionally been thought to participate in the
inflammatory response only as an effi'ctor cell. However, recent data demonstrate that PMNs …

Neutrophil granule proteins tune monocytic cell function

O Soehnlein, C Weber, L Lindbom - Trends in immunology, 2009 - cell.com
Polymorphonuclear leukocytes (PMNs) release the contents of granules during their
migration to inflammatory sites. On liberation from the first leukocyte to enter injured tissue …

[HTML][HTML] The neutrophil: constant defender and first responder

N Fine, N Tasevski, CA McCulloch… - Frontiers in …, 2020 - frontiersin.org
The role of polymorphonuclear neutrophils (PMNs) in biology is often recognized during
pathogenesis associated with PMN hyper-or hypo-functionality in various disease states …