Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy
WQ Qiu, W Ai, FD Zhu, Y Zhang, MS Guo… - Free Radical Biology …, 2022 - Elsevier
Activation of the NLRP3 inflammasome and its mediated neuroinflammation are implicated
in neurodegenerative diseases, while mitophagy negatively regulates NLRP3 …
in neurodegenerative diseases, while mitophagy negatively regulates NLRP3 …
Punicalagin attenuates LPS-induced inflammation and ROS production in microglia by inhibiting the MAPK/NF-κB signaling pathway and NLRP3 inflammasome …
J Lo, CC Liu, YS Li, PY Lee, PL Liu, PC Wu… - Journal of …, 2022 - Taylor & Francis
Purpose Neurodegenerative diseases are associated with neuroinflammation along with
activation of microglia and oxidative stress, but currently lack effective treatments …
activation of microglia and oxidative stress, but currently lack effective treatments …
[HTML][HTML] Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction
WQ Qiu, R Pan, Y Tang, XG Zhou, JM Wu, L Yu… - Biomedicine & …, 2020 - Elsevier
Emerging evidence indicates that the enhancement of microglial autophagy inhibits the
NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD) …
NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD) …
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease
X Han, S Sun, Y Sun, Q Song, J Zhu, N Song, M Chen… - Autophagy, 2019 - Taylor & Francis
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …
periphery predisposes individuals to the development of neurodegenerative disorders …
Astragalin exerted antidepressant-like action through SIRT1 signaling modulated NLRP3 inflammasome deactivation
Y Tong, H Fu, C Xia, W Song, Y Li, J Zhao… - ACS chemical …, 2020 - ACS Publications
Inflammation plays a key role in the pathogenesis of depression and antidepressant
therapies. Astragalin (AST) is a bioactive flavonoid that possesses an anti-inflammatory …
therapies. Astragalin (AST) is a bioactive flavonoid that possesses an anti-inflammatory …
TSPO ligands PK11195 and midazolam reduce NLRP3 inflammasome activation and proinflammatory cytokine release in BV-2 cells
H Feng, Y Liu, R Zhang, Y Liang, L Sun… - Frontiers in Cellular …, 2020 - frontiersin.org
Neuroinflammation related to microglial activation plays an important role in
neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive …
neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive …
Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson …
Cellular communication linking microglia activation and dopaminergic neuronal loss play an
imperative role in the progression of Parkinson's disease (PD); however, underlying …
imperative role in the progression of Parkinson's disease (PD); however, underlying …
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway
Y Gao, J Li, J Li, C Hu, L Zhang, J Yan, L Li… - Biochemical …, 2020 - Elsevier
Alzheimer's disease (AD) is an irreversible neurodegenerative brain disorder with complex
pathogenesis. The fibrillar peptide β-amyloid (Aβ) has a chief function in the pathogenesis of …
pathogenesis. The fibrillar peptide β-amyloid (Aβ) has a chief function in the pathogenesis of …
Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors
J Wang, D Wang, Z Zhou, X Zhang, C Zhang… - Neurochemistry …, 2021 - Elsevier
Obesity is characterized by a condition of low-grade chronic inflammation that facilitates
development of numerous comorbidities and dysregulation of brain homeostasis. It is …
development of numerous comorbidities and dysregulation of brain homeostasis. It is …
Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia
Z Fan, Z Liang, H Yang, Y Pan, Y Zheng… - Journal of …, 2017 - Springer
Background Emerging evidence indicates that nod-like receptor family, pyrin domain-
containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the …
containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the …