Stellate cells and immune cells are both active participants in the pathogenesis of liver
disease. Interactions between these two populations are important determinants of disease …

Following acute or chronic liver tissue damage, hepatic stellate cells (HSCs) undergo a
process of activation toward a phenotype characterized by increased proliferation, motility …

Background & Aims Myeloid derived suppressor cells (MDSCs) are a heterogeneous
population of cells associated with the suppression of immunity. However, little is known …

Recent functional research studies suggest an anti-fibrotic role for natural killer (NK) cells
coupled with a profibrotic role for CD8 cells. However, the morphological cellular interplay …

Liver sinusoidal endothelial cells (LSEC) are unique organ‐resident antigen‐presenting
cells capable of cross‐presentation and subsequent tolerization of naïve CD8+ T cells. We …

Background & Aims: Hepatic stellate cells play an important role in liver fibrogenesis, and
hepatic stellate cell death may be involved in the termination of this response. Methods …

Hepatic stellate cells (HSCs) are critical for hepatic wound repair and tissue remodeling.
They also produce cytokines and chemokines that may contribute to the maintenance of …

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …

Chronic hepatitis C virus (HCV) infection can cause liver damage, ranging from mild to more
severe conditions, such as fibrosis and cirrhosis. Hepatic stellate cell (HSC) activation is a …

Increased CD8‐T lymphocytes and reduced natural killer (NK) cells contribute to hepatic
fibrosis. We have characterized pathways regulating the interactions of human hepatic …