Increased CD8‐T lymphocytes and reduced natural killer (NK) cells contribute to hepatic
fibrosis. We have characterized pathways regulating the interactions of human hepatic …

Over the last two decades, our understanding of the pathological role of hepatic stellate cells
(HSCs) in fibrotic liver disease has increased dramatically. As HSCs are identified as the …

Acute self-limiting and chronic liver injury are both associated with activation and
proliferation of hepatic stellate cells (HSCs). In chronic injury, activated stellate cells are the …

Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …

Background & Aims: Following hepatic injury, hepatic stellate cells (HSCs) transdifferentiate
to become extracellular matrix-producing myofibroblasts and to promote hepatic …

Hepatic stellate cells (HSC), a pericyte-like nonparenchymal liver cell population, are
regarded as the principal matrix-synthesizing cells of fibrotic liver. They might also play a …

Background & Aims NK cells regulate liver fibrosis by killing activated hepatic stellate cells
(HSCs) and are controlled themselves by immune cells and/or soluble factors. Here, we …

Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to liver
fibrosis. Here, we postulated that the immune regulatory properties of HSCs might promote …

Background & Aims Hepatic infiltration of neutrophils is a hallmark of steatohepatitis;
however, the role of neutrophils in the progression of steatohepatitis remains unknown …

Increasing evidence in recent years has suggested that B cells act as a crucial regulator in
autoimmune diseases. However, little is known about their role in autoimmune hepatitis …