BACKGROUND & AIMS: The liver can mitigate the inflammatory activity of infiltrating T cells
by mechanisms that are not entirely clear. Here we investigated the role of liver sinusoidal …

Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ
fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand …

We investigated whether transplanted hepatocytes interact with hepatic stellate cells, as cell–
cell interactions could modulate their engraftment in the liver. We transplanted Fischer 344 …

The liver has long been described as immunosuppressive, although the mechanisms
underlying this phenomenon are incompletely understood. Hepatic stellate cells (HSCs), a …

Hepatic stellate cells are believed to play a key role in the development of liver fibrosis.
Several studies have reported that bone marrow cells can give rise to hepatic stellate cells …

Hepatic stellate cells (HSCs) constitute the liver sinusoid with Kupffer cells and liver
sinusoidal endothelial cells. While the sinusoid functions as the gateway to liver …

Background/Aims: Activation of the transcription factor NFκB has been demonstrated in
activated hepatic stellate cells (HSCs). We investigated the role of NFκB in proliferation, in …

Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis,
characterized by enhanced extracellular matrix production and altered degradation …

Upon systemic activation by antigens, CD8+, but not CD4+, T cells selectively accumulate
and undergo apoptosis in the liver, a mechanism associated with the induction of hepatic …

Autoimmune hepatitis (AIH) is known as a T cell–mediated disease. However, AIH patients
refractory to conventional treatment have been successfully treated with anti‐CD20 …