Technologies for measuring red blood cell deformability

K Matthews, ES Lamoureux, ME Myrand-Lapierre… - Lab on a Chip, 2022 - pubs.rsc.org
Human red blood cells (RBCs) are approximately 8 μm in diameter, but must repeatedly
deform through capillaries as small as 2 μm in order to deliver oxygen to all parts of the …

Integrated automated particle tracking microfluidic enables high‐throughput cell deformability cytometry for red cell disorders

P Guruprasad, RG Mannino, C Caruso… - American journal of …, 2019 - Wiley Online Library
Investigating individual red blood cells (RBCs) is critical to understanding hematologic
diseases, as pathology often originates at the single‐cell level. Many RBC disorders …

Advances in the measurement of red blood cell deformability: A brief review

J Kim, HY Lee, S Shin - Journal of Cellular Biotechnology, 2015 - content.iospress.com
Red blood cells (RBCs) exhibit a unique deformability, which enables them to change shape
reversibly in response to an external force. The deformability of RBCs allows them to flow in …

Multiplexed fluidic plunger mechanism for the measurement of red blood cell deformability

ME Myrand-Lapierre, X Deng, RR Ang, K Matthews… - Lab on a Chip, 2015 - pubs.rsc.org
The extraordinary deformability of red blood cells gives them the ability to repeatedly transit
through the microvasculature of the human body. The loss of this capability is part of the …

Measurement techniques for red blood cell deformability: recent advances

Y Kim, K Kim, Y Park - Blood Cell—An Overview of Studies in …, 2012 - books.google.com
Human red blood cells (RBCs) or erythrocytes have remarkable deformability. Upon external
forces, RBCs undergo large mechanical deformation without rupture, and they restore to …

Microfluidic deformability analysis of the red cell storage lesion

K Matthews, ME Myrand-Lapierre, RR Ang… - Journal of …, 2015 - Elsevier
A key challenge in transfusion medicine research and clinical hematology is to develop a
simple and non-destructive method to measure the quality of each blood unit prior to use …

Biomechanical properties of red blood cells in health and disease towards microfluidics

G Tomaiuolo - Biomicrofluidics, 2014 - pubs.aip.org
Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to
navigate across various human microcirculation vessels, enabling them to pass through …

Microfluidic analysis of red blood cell deformability

Q Guo, SP Duffy, K Matthews, AT Santoso… - Journal of …, 2014 - Elsevier
A common indicator of rheological dysfunction is a measurable decrease in the deformability
of red blood cells (RBCs). Decreased RBC deformability is associated with cellular stress or …

A system for the high-throughput measurement of the shear modulus distribution of human red blood cells

A Saadat, DA Huyke, DI Oyarzun, PV Escobar… - Lab on a Chip, 2020 - pubs.rsc.org
Reduced deformability of red blood cells (RBCs) can affect the hemodynamics of the
microcirculation and reduce oxygen transport efficiency. It is also well known that reduced …

Microfluidic analysis of cellular deformability of normal and oxidatively damaged red blood cells

JM Kwan, Q Guo, DL Kyluik‐Price… - American journal of …, 2013 - Wiley Online Library
Microfluidic analysis of blood has potential clinical value for determining normal and
abnormal erythrocyte deformability. To determine if a microfluidic device could reliably …