Platinum (II) complexes with mono-aminophosphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: synthesis, crystal structure and …
KB Huang, ZF Chen, YC Liu, ZQ Li, JH Wei… - European Journal of …, 2013 - Elsevier
Six new platinum (II) complexes with mono-aminophosphonate ester were synthesized and
characterized by elemental analysis, 1H NMR, ESI-MS as well as single crystal X-ray …
characterized by elemental analysis, 1H NMR, ESI-MS as well as single crystal X-ray …
Enhancing cytotoxicity of a monofunctional platinum complex via a dual-DNA-damage approach
Y Guo, Y He, S Wu, S Zhang, D Song, Z Zhu… - Inorganic …, 2019 - ACS Publications
Mitochondrial DNA (mtDNA) is an attractive cellular target for anticancer agents in addition
to nuclear DNA (nDNA). The cationic platinum (II) complex cis-[Pt (NP)(NH3) 2Cl] NO3 …
to nuclear DNA (nDNA). The cationic platinum (II) complex cis-[Pt (NP)(NH3) 2Cl] NO3 …
[HTML][HTML] Enhanced anticancer potency with reduced nephrotoxicity of newly synthesized platin-based complexes compared with cisplatin
As a platinum-containing anticancer drug, cisplatin is the keystone for treating many
malignancies. Nephrotoxicity is the main dose-limiting toxicity, and several hydration …
malignancies. Nephrotoxicity is the main dose-limiting toxicity, and several hydration …
[HTML][HTML] Diplatin, a Novel and Low-Toxicity Anti-Lung Cancer Platinum Complex, Activation of Cell Death in Tumors via a ROS/JNK/p53-Dependent Pathway, and a …
X Lin, Y Jia, X Dong, J Shen, Y Jin, Y Li… - Frontiers in …, 2019 - frontiersin.org
Background: Platinum-based drugs prevail as the main treatment of lung cancer; this is
caused by their relative effectiveness despite known side effects, such as neurotoxicity. The …
caused by their relative effectiveness despite known side effects, such as neurotoxicity. The …
Preclinical toxicology and tissue platinum distribution of novel oral antitumour platinum complexes: ammine/amine platinum (IV) dicarboxylates
MJ McKeage, SE Morgan, FE Boxall, BA Murrer… - Cancer chemotherapy …, 1994 - Springer
The preclinical toxicology and tissue platinum distribution of a series of six orally given
antitumour platinum complexes [ammine/amine platinum (IV) dicarboxylates] with structural …
antitumour platinum complexes [ammine/amine platinum (IV) dicarboxylates] with structural …
[HTML][HTML] A new platinum (II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells
A Muscella, C Vetrugno, FP Fanizzi, C Manca… - Cell Death & …, 2013 - nature.com
Abstract [Pt (O, O′-acac)(γ-acac)(DMS)](PtAcD) is able to induce apoptosis in various
human cancer cells, including the cisplatin-resistant human breast carcinoma MCF-7 cells …
human cancer cells, including the cisplatin-resistant human breast carcinoma MCF-7 cells …
Design and biological features of platinum (II) complexes with 3-hydroxy-3-(Trifluoromethyl) cyclobutane-1, 1-Dicarboxylate as a leaving ligand
F Liu, C Yang, S Li, X Wu, K Xue, Y Zhou… - European Journal of …, 2022 - Elsevier
A series of platinum compounds 2a-5a and 2b-5b with fluoro-functional groups are designed
and synthesized. Among them, complex 2b is the most effective agent with 3-hydroxy-3 …
and synthesized. Among them, complex 2b is the most effective agent with 3-hydroxy-3 …
A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium (II) barbiturate complex
Autophagy is a catabolic process for cells that can provide energy sources and allows
cancer cells to evade cell death. Therefore, studies on the combination of autophagy …
cancer cells to evade cell death. Therefore, studies on the combination of autophagy …
Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt (IV) derivative of oxaliplatin
J Zajac, H Kostrhunova, V Novohradsky… - Journal of Inorganic …, 2016 - Elsevier
The molecular and cellular mechanisms of enhanced toxic effects in tumor cells of the Pt (IV)
derivatives of antitumor oxaliplatin containing axial dichloroacetate (DCA) ligands were …
derivatives of antitumor oxaliplatin containing axial dichloroacetate (DCA) ligands were …
Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB
R He, X Shi, M Zhou, Y Zhao, S Pan, C Zhao… - Toxicology and applied …, 2018 - Elsevier
The lysosome is emerging as a central regulator of the autophagic process, which plays a
critical role in tumor growth and chemoresistance. Alantolactone, which is a natural …
critical role in tumor growth and chemoresistance. Alantolactone, which is a natural …