N-heterocyclic carbenes-modified half-sandwich iridium (III) complex [(η 5-C 5 Me 4 C 6 H 4
C 6 H 5) Ir (C^ C) Cl] PF 6 (C1)(where C^ C is a N-heterocyclic carbene ligand) can …

Several new R2eddp (R= i-Pr, i-Bu; eddp= ethylenediamine-N, N′-di-3-propionate) esters
and corresponding platinum (ii) and platinum (iv) complexes of the general formula [PtCl n …

Our study demonstrates that Pt (IV) derivative of cisplatin, with two axial PhB ligands, ctc-[Pt
(NH3) 2 (PhB) 2Cl2], is a very potent cytotoxic agent against many different human cancer …

In this work, we present the first study about the interactions of mitochondria-damaging Pt
(IV) prodrugs with cytochrome c. We synthesized a cisplatin-based Pt (IV) prodrug bearing a …

Background: The Akt/mammalian target of rapamycin (mTOR) signalling pathway serves as
a critical regulator of cellular growth, proliferation and survival. Akt aberrant activation has …

Piperlongumine (PL), a natural alkaloid present in the fruit of the Long pepper, is known to
exhibit notable anti-cancer effects. Nonetheless, the anti-tumor effect of PL in lung cancer …

The current work investigates the influence of novel dinuclear platinum (II) compounds of
structure: Pt2 (3-ethylpyridine) 4 (berenil) 2 (Pt10) and Pt2 (3-butylpyridine) 4 (berenil) 2 …

Cisplatin and other platinum‐based drugs are well‐known valid anticancer drugs. However,
during chemotherapy, the presence of numerous side effects and the onset of frequent …

We previously reported that marchantin M (Mar) is an active agent to induce apoptosis in
human prostate cancer (PCa), but the molecular mechanisms of action remain largely …

Polynuclear platinum complexes constitute a special class of hopeful antitumor agents. In
this study, a Y-type monofunctional trinuclear platinum complex (MTPC) with 1, 3, 5-tris …