Pharmacological studies have been focused on the involvement of different neural pathways
in the organization of antinociception that follows tonic-clonic seizures, including 5 …

The post-ictal immobility syndrome is followed by a significant increase in the nociceptive
thresholds in animals and humans. The aim of this study was to assess the involvement of …

The role of the acetylcholine-mediated system in the organization of postictal antinociception
was investigated. For this purpose, nicotinic and muscarinic cholinergic receptor antagonists …

The blockade of GABA-mediated Cl− influx with pentylenetetrazol (PTZ) was used in the
present work to induce seizures in Rattus norvegicus. The aim of this work was to study the …

The periaqueductal gray matter (PAG) consists in a brainstem structure rich in 5‐
hydroxytryptamine (5‐HT) inputs related to the modulation of pain. The involvement of each …

Microinjections of N-methyl-d-aspartic acid (NMDA) in the midbrain tectum structures
produce panic attack-like defensive behaviours, followed by an antinociceptive response. It …

The deep layers of the superior colliculus (DLSC) and the dorsal periaqueductal gray matter
(DPAG) have been implicated in the control of defensive-like behaviors. Electrical and …

The postictal state is generally followed by antinociception. It is known that connections
between the dorsal raphe nucleus, the periaqueductal gray matter, and the locus coeruleus …

The serotonin-containing raphe-spinal pathway has been implicated as playing an important
role in analgesia. Several studies, however, have reported the inefficacy of traditional …

The effects of 5-hydroxytryptamine (5-HT) and ligands selective for particular 5-HT receptor
subtypes on the transmission of nociceptive information in the spinal cord are complex. In …