Opiate-like substances mediate norepinephrine-induced but not serotonin-induced antinociception at spinal level Reevaluation by an electrophysiological model of …
J Ma, J Qiao, N Dafny - Life Sciences, 2001 - Elsevier
After subcutaneous injection of formalin (5%, 50 μl) into a hindpaw of rats, biphasic
excitatory nociceptive discharges were recorded extracellularly in thalamic parafascicular …
excitatory nociceptive discharges were recorded extracellularly in thalamic parafascicular …
Involvement of pre-and post-synaptic serotonergic receptors of dorsal raphe nucleus neural network in the control of the sweet-substance-induced analgesia in adult …
CI Miyase, R Kishi, RL de Freitas, DA Paz… - Neuroscience …, 2005 - Elsevier
In order to investigate the effects of monoaminergic mechanisms of the dorsal raphe nucleus
on the elaboration and control of sweet-substance-induced antinociception, male albino …
on the elaboration and control of sweet-substance-induced antinociception, male albino …
Role of muscarinic and nicotinic cholinergic receptors in an experimental model of epilepsy-induced analgesia
RL de Freitas, RC de Oliveira, AD de Carvalho… - Pharmacology …, 2004 - Elsevier
The blockade of GABA-mediated Cl− influx with pentylenetetrazol (PTZ) was used in the
present work to induce seizures in animals. The neurotransmission in the postictal period …
present work to induce seizures in animals. The neurotransmission in the postictal period …
Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn
T Fukushima, T Ohtsubo, M Tsuda… - Journal of …, 2009 - journals.physiology.org
Analgesic effects of serotonin (5-hydroxytryptamine [5-HT]) type 3 (5-HT3) receptors may
involve the release of γ-aminobutyric acid (GABA) in the spinal dorsal horn. However, the …
involve the release of γ-aminobutyric acid (GABA) in the spinal dorsal horn. However, the …
[HTML][HTML] Modality selective roles of pro-nociceptive spinal 5-HT2A and 5-HT3 receptors in normal and neuropathic states
R Patel, AH Dickenson - Neuropharmacology, 2018 - Elsevier
Descending brainstem control of spinal nociceptive processing permits a dynamic and
adaptive modulation of ascending sensory information. Chronic pain states are frequently …
adaptive modulation of ascending sensory information. Chronic pain states are frequently …
The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat
KL Hoskin, GA Lambert, C Donaldson, AS Zagami - Brain research, 2004 - Elsevier
Migraine pain arises in the trigeminovascular system and is often associated with nausea
and sometimes with vomiting. In this study, an in vivo cat model of trigeminovascular …
and sometimes with vomiting. In this study, an in vivo cat model of trigeminovascular …
Role of the nucleus raphe magnus in antinociception produced by ABT-594: immediate early gene responses possibly linked to neuronal nicotinic acetylcholine …
RS Bitner, AL Nikkel, P Curzon, SP Arneric… - Journal of …, 1998 - Soc Neuroscience
Recently, a novel cholinergic channel modulator,(R)-5-(2-azetidinylmethoxy)-2-
chloropyridine (ABT-594), was shown to produce potent analgesia in a variety of rodent pain …
chloropyridine (ABT-594), was shown to produce potent analgesia in a variety of rodent pain …
Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test
M Sasaki, K Ishizaki, H Obata, F Goto - European journal of pharmacology, 2001 - Elsevier
We used the formalin test to clarify the 5-hydroxytryptamine (5-HT) receptor subtypes
involved in the modulation of spinal nociceptive transmission in rats. Intrathecal …
involved in the modulation of spinal nociceptive transmission in rats. Intrathecal …
Microiontophoretically applied 5-HT reduces responses to noxious stimulation in the thalamus.
E Andersen, N Dafny - Brain Research, 1982 - psycnet.apa.org
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is thought to be involved in a descending
pain modulation system from the brain stem to the spinal cord. However, supraspinal …
pain modulation system from the brain stem to the spinal cord. However, supraspinal …
Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT1 receptors
JCA Edvinsson, A Maddahi, IM Christiansen… - The Journal of …, 2022 - Springer
Abstract Background 5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in
migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans …
migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans …