Nowadays, lung cancer is the most common cause of cancer-related deaths in both men
and women globally. Despite the development of extremely efficient targeted agents, lung …

Although in the last few decades we have witnessed the rapid development of treatments for
non-small cell lung cancer (NSCLC), it still remains the leading cause of cancer-related …

FOXO transcription factors, functioning downstream of the PI3K-PTEN-AKT (PKB) signalling
cascade, are essential for cell proliferation, differentiation, DNA damage repair and …

Lung cancer is one of the most common cancers in the world, which accounts for about 27%
of all cancer deaths. However, the mechanisms underlying the pathogenesis of lung cancer …

FoxM1 is a member of the Forkhead box (Fox) family of transcription factors, which is
expressed in actively dividing cells and is critical for cell cycle progression. Increased …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Forkhead box O (FOXO) family has recently been highlighted as important transcriptional
regulators associated with many diverse carcinomas. Although redundant functionality …

Objectives FOXM1 is a key member of the FOX transcription factor family, which plays a vital
role in a series of physiological processes. In the present study, non-small cell lung cancer …

Abstract Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition
and M phase progression in the cell cycle, plays a principal role in many physiological and …

FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …