The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies

M Muzza, D Degl'Innocenti, C Colombo… - Clinical …, 2010 - Wiley Online Library
Objective The recent concept that oncogenes responsible for thyroid neoplastic
transformation are able to elicit an inflammatory protumourigenic microenvironment raises …

The thyroid gland: a crossroad in inflammation-induced carcinoma? An ongoing debate with new therapeutic potential.

A Bozec, S Lassalle, V Hofman, M Ilie… - Current medicinal …, 2010 - ingentaconnect.com
Chronic infection and inflammation contribute to around 25% of cancer cases worldwide.
While a direct link between several types of human malignancies and inflammation has now …

Thyroid cancer and inflammation

V Guarino, MD Castellone, E Avilla… - Molecular and cellular …, 2010 - Elsevier
Some cancer types are strongly associated with chronic inflammatory or infectious diseases
whereas others are not, but an inflammatory component is present in most human neoplastic …

[HTML][HTML] Clinical and pathological implications of concurrent autoimmune thyroid disorders and papillary thyroid cancer

LL Cunha, RC Ferreira, MA Marcello… - Journal of thyroid …, 2011 - ncbi.nlm.nih.gov
Cooccurrences of chronic lymphocytic thyroiditis (CLT) and thyroid cancer (DTC) have been
repeatedly reported. Both CLT and DTC, mainly papillary thyroid carcinoma (PTC), share …

Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene

MG Borrello, L Alberti, A Fischer… - Proceedings of the …, 2005 - National Acad Sciences
Rearrangements of the RET receptor tyrosine kinase gene generating RET/PTC oncogenes
are specific to papillary thyroid carcinoma (PTC), the most frequent thyroid tumor. Here, we …

Thyroid autoimmune disorders and cancer

SM Ferrari, P Fallahi, G Elia, F Ragusa, I Ruffilli… - Seminars in cancer …, 2020 - Elsevier
In the last decades, many studies conducted in vitro, and in vivo, have shown that thyroid
autoimmunity and thyroid cancer (TC)(mainly papillary TC) can be concomitant, even if the …

RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of …

KJ Rhoden, K Unger, G Salvatore… - The Journal of …, 2006 - academic.oup.com
Context: RET/papillary thyroid cancer (PTC) is a marker for papillary thyroid carcinoma, but
its specificity has been questioned because of the disputed identification of RET/PTC in …

Thyroid autoimmunity and thyroid cancer–the pathogenic connection: a 2018 update

Y Nagayama - Hormone and Metabolic Research, 2018 - thieme-connect.com
The association between thyroid cancer and thyroid autoimmunity has long been suggested,
but remains to be elucidated for several decades. Here the data on this issue are updated by …

Thyroid cancer and thyroid autoimmune disease: A review of molecular aspects and clinical outcomes

NMD Lopes, HHM Lens, A Armani, PC Marinello… - … -Research and Practice, 2020 - Elsevier
Thyroid cancer (TC) is the most prevalent malignant neoplasm that affects the endocrine
system. Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is the …

RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response

E Puxeddu, JA Knauf, MA Sartor… - Endocrine-Related …, 2005 - erc.bioscientifica.com
RET/PTC rearrangements represent key genetic events involved in papillary thyroid
carcinoma (PTC) initiation. The aim of the present study was to identify the early changes in …