Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity
RM Aly, RAT Serya, AM El-Motwally, A Esmat… - Bioorganic …, 2017 - Elsevier
EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
Design and Synthesis of some new 2, 4, 6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents
HA Allam, EE Aly, AK Farouk, AM El Kerdawy… - Bioorganic …, 2020 - Elsevier
The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study
Abstract A Ta 2 O 5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity
DA Ibrahim, DA Abou El Ella, AM El-Motwally… - European Journal of …, 2015 - Elsevier
EGFR, which plays a vital role as a regulator of cell growth, is one of the intensely studied TK
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-tetrahydroquinoline as potential …
Y OuYang, W Zou, L Peng, Z Yang, Q Tang… - European Journal of …, 2018 - Elsevier
Eight series of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing oxazole or imidazole as potential EGFR inhibitors
Y OuYang, C Wang, B Zhao, H Xiong, Z Xiao… - New Journal of …, 2018 - pubs.rsc.org
Six series of quinazoline derivatives bearing oxazole or imidazole (8a–f, 9a–f, 10a–d, 11a–f,
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …
Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors
ZY Fang, YH Zhang, CH Chen, Q Zheng… - Chemistry & …, 2022 - Wiley Online Library
A series of novel quinazolinone hydrazide derivatives were designed and synthesized as
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer …
New acetamide (IV ae) and 1, 3-thiazolidinone derivatives (VII ae) were designed,
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
MAA El-Sayed, WM El-Husseiny… - Journal of enzyme …, 2018 - Taylor & Francis
Abstract A new series of 4, 6-disubstituted 2-(4-(dimethylamino) styryl) quinoline 4a, b–9a, b
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
[PDF][PDF] Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
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